Livrea P, Puca F M, Barnaba A, Di Reda L
Eur Neurol. 1977;15(2):71-6. doi: 10.1159/000114792.
A case of Kleine-Levin syndrome with true hypersomnia and a case of sub-wakefulness are described. In both patients lumbar cerebrospinal fluid homovanillic acid, 5-hydroxyindoleacetic acid, 3-methoxy-4-hydroxyphenylethylene glycol levels have been assayed during episodes of hypersomnia and normal sleep-waking cycles. Besides an increased 5-hydroxytryptamine turnover, mainly an increased dopamine turnover has been detected in both kinds of hypersomnia, and this finding was more remarkable in the case with sub-wakefulness. The probable role of dopamine in abnormalities in the sleep-waking cycle is discussed on the basis of results in experimental animal hypersomnias.
本文描述了一例伴有真性嗜睡的克莱恩-莱文综合征病例和一例亚觉醒状态病例。在这两名患者中，分别在嗜睡发作期和正常睡眠-觉醒周期测定了腰椎脑脊液中高香草酸、5-羟吲哚乙酸、3-甲氧基-4-羟基苯乙二醇的水平。除了5-羟色胺周转率增加外，在这两种嗜睡状态中均检测到多巴胺周转率主要增加，且这一发现在亚觉醒状态病例中更为显著。基于实验性动物嗜睡症的研究结果，讨论了多巴胺在睡眠-觉醒周期异常中的可能作用。
