Faull K F, Guilleminault C, Berger P A, Barchas J D
Ann Neurol. 1983 Mar;13(3):258-63. doi: 10.1002/ana.410130306.
Two groups of patients with the common complaint of excessive daytime sleepiness were examined. One group fulfilled the criteria for narcolepsy. The other had the sole symptom of excessive daytime sleepiness, confirmed by sleep latency tests, which was unaccompanied by systemic illness. Spinal fluid examinations for homovanillic acid, 3,4-dihydroxyphenylacetic acid, 3-methoxy-4-hydroxyphenylethylene glycol, and 5-hydroxyindoleacetic acid were carried out before and after administration of probenecid on the 20 patients and 40 controls. Probenecid-corrected accumulation of the dopamine metabolites was significantly increased in each of the patient groups, suggesting an association between pathological sleepiness and elevated dopamine turnover in the central nervous system.
对两组主诉白天过度嗜睡的患者进行了检查。一组符合发作性睡病的标准。另一组仅有白天过度嗜睡的症状，经睡眠潜伏期测试证实，且无全身性疾病。对20例患者和40例对照者在服用丙磺舒前后进行了脑脊液中高香草酸、3,4-二羟基苯乙酸、3-甲氧基-4-羟基苯乙二醇和5-羟基吲哚乙酸的检测。丙磺舒校正后的多巴胺代谢产物蓄积在每组患者中均显著增加，提示病理性嗜睡与中枢神经系统多巴胺周转率升高之间存在关联。
