Mascheroni D, Kolobow T, Fumagalli R, Moretti M P, Chen V, Buckhold D
National Institutes of Health, Laboratory of Technical Development, Bethesda, Maryland.
Intensive Care Med. 1988;15(1):8-14. doi: 10.1007/BF00255628.
The pulmonary effects of hyperventilation following infusion of sodium salicylate into the cisterna magna was studied in 16 spontaneously breathing adult sheep. We found a fall in PaO2, a decrease in the static compliance of the respiratory system, abnormal chest roentgenographic films, and grossly abnormal lungs following 3.5 to 13 h of hyperventilation. A control group of 15 sheep (10 sheep similarly injected with sodium salicylate, but then sedated and paralyzed and ventilated at normal tidal volume and respiratory rate on a mechanical ventilator, and 5 sheep infused with saline alone and breathing spontaneously) showed no pulmonary or arterial blood gas abnormalities. We conclude that prolonged hyperventilation under the conditions of this experiment precipitated events that resulted in acute lung injury.
在16只自主呼吸的成年绵羊中研究了向小脑延髓池注入水杨酸钠后过度通气对肺部的影响。我们发现，在过度通气3.5至13小时后，动脉血氧分压（PaO2）下降、呼吸系统静态顺应性降低、胸部X光片异常以及肺部出现严重异常。一个由15只绵羊组成的对照组（10只绵羊同样注射了水杨酸钠，但随后使用机械通气机以正常潮气量和呼吸频率进行镇静、麻痹和通气，另外5只绵羊仅注入生理盐水并自主呼吸）未出现肺部或动脉血气异常。我们得出结论，在本实验条件下的长时间过度通气引发了导致急性肺损伤的事件。
