Medical School, Nankai University, Tianjin, China.
ColIege of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, China.
Acta Otolaryngol. 2020 Jul;140(7):564-569. doi: 10.1080/00016489.2020.1743878. Epub 2020 Apr 17.
Tinnitus was a subjective auditory phantom phenomenon which could be highly distressing and had no objective indicators for evaluation. The aim of this study was to investigate whether and how did electroencephalography (EEG) microstates of subjective tinnitus patients change in resting state and whether could be an objective indicator for tinnitus. We enrolled chronic subjective tinnitus patients and matched age and gender with healthy controls. EEG recording, microstate analysis and statistical analysis were performed. We finally had 10 male and 8 female age-matched participants in tinnitus group and healthy control group. Statistical differences were found in the microstate A, C and D durations between the two groups (class A, = .024; class B, = .018; class D, = .029). Microstate durations of class A and D had linear correlation with VAS scores in tinnitus patients (microstate A [R spare = 0.43, = .003*]; microstate D [R spare = 0.46, = .002*]). Microstates had changed in chronic tinnitus patients and provided an indicator or perspective to explore the mechanisms of tinnitus. The maintenance of chronic subjective tinnitus may be related to changes in cerebral cortex activity.
耳鸣是一种主观的听觉幻觉现象，可能会带来极大的困扰，且没有客观的评估指标。本研究旨在探讨慢性主观性耳鸣患者静息状态下的脑电微状态是否以及如何发生改变，能否成为耳鸣的客观指标。我们纳入了慢性主观性耳鸣患者，并按年龄和性别与健康对照组进行匹配。进行了脑电图记录、微状态分析和统计分析。我们最终纳入了 10 名男性和 8 名女性年龄匹配的耳鸣组和健康对照组参与者。两组间的微状态 A、C 和 D 的持续时间存在统计学差异（A 类， =.024；B 类， =.018；D 类， = .029）。微状态 A 和 D 的持续时间与耳鸣患者的 VAS 评分呈线性相关（微状态 A [R spare = 0.43， = .003*]；微状态 D [R spare = 0.46， = .002*]）。慢性耳鸣患者的微状态发生了改变，为探索耳鸣机制提供了一个指标或视角。慢性主观性耳鸣的维持可能与大脑皮层活动的改变有关。
