Zhang Chi, Wang Xiaoguang, Ding Zhiwei, Zhou Hanwen, Liu Peng, Xue Xinmiao, Wang Li, Jiang Yuke, Chen Jiyue, Shen Weidong, Yang Shiming, Wang Fangyuan
The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Zhan Tan Temple Outpatient Department, Central Medical Branch of PLA General Hospital, Beijing, China.
Front Neurosci. 2023 Apr 6;17:1159019. doi: 10.3389/fnins.2023.1159019. eCollection 2023.
Tinnitus is closely associated with cognition functioning. In order to clarify the central reorganization of tinnitus in patients with vestibular schwannoma (), this study explored the aberrant dynamics of electroencephalogram (EEG) microstates and their correlations with tinnitus features in patients. Clinical and EEG data were collected from 98 patients, including 76 with tinnitus and 22 without tinnitus. Microstates were clustered into four categories. Our EEG microstate analysis revealed that patients with tinnitus exhibited an increased frequency of microstate C compared to those without tinnitus. Furthermore, correlation analysis demonstrated that the Tinnitus Handicap Inventory (THI) score was negatively associated with the duration of microstate A and positively associated with the frequency of microstate C. These findings suggest that the time series and syntax characteristics of EEG microstates differ significantly between patients with and without tinnitus, potentially reflecting abnormal allocation of neural resources and transition of functional brain activity. Our results provide a foundation for developing diverse treatments for tinnitus in patients.
耳鸣与认知功能密切相关。为了阐明前庭神经鞘瘤患者耳鸣的中枢重组情况，本研究探讨了98例患者脑电图（EEG）微状态的异常动态及其与耳鸣特征的相关性。收集了98例患者的临床和脑电图数据，其中76例有耳鸣，22例无耳鸣。微状态被分为四类。我们的脑电图微状态分析显示，与无耳鸣患者相比，耳鸣患者的微状态C频率增加。此外，相关性分析表明，耳鸣障碍量表（THI）得分与微状态A的持续时间呈负相关，与微状态C的频率呈正相关。这些发现表明，有耳鸣和无耳鸣患者之间脑电图微状态的时间序列和句法特征存在显著差异，这可能反映了神经资源的异常分配和大脑功能活动的转变。我们的结果为开发针对耳鸣患者的多样化治疗方法提供了基础。
