Sitaram N, Buchsbaum M S, Gillin J C
Eur J Pharmacol. 1977 Apr 7;42(3):285-90. doi: 10.1016/0014-2999(77)90295-3.
14 normal volunteers were given 0.5 mg physostigmine or saline placebo i.v. in a randomized double blind trial. Subjects were pretreated with 0.5 mg methscopolamine i.m. on both days. Pain ratings and average evoked responses were obtained to brief electrical stimuli administered to the forearm. Pain response criterion was significantly higher on physostigmine than on placebo. Average evoked response component P100 was significantly smaller on physostigmine than placebo, especially for higher intensity stimuli. These results are consistent with central cholinergic modulation of pain and arousal systems in man.
在一项随机双盲试验中，14名正常志愿者静脉注射0.5毫克毒扁豆碱或生理盐水安慰剂。两天均预先肌肉注射0.5毫克甲基东莨菪碱。对施加于前臂的短暂电刺激进行疼痛评分和平均诱发反应测量。毒扁豆碱组的疼痛反应标准显著高于安慰剂组。毒扁豆碱组的平均诱发反应成分P100显著小于安慰剂组，尤其是对于高强度刺激。这些结果与人的疼痛和觉醒系统的中枢胆碱能调节相一致。
