Rausch J L, Janowsky D S, Risch S C, Huey L Y
Eur J Pharmacol. 1985 Feb 12;109(1):91-6. doi: 10.1016/0014-2999(85)90543-6.
Platelet serotonin (5HT) uptake was measured in 18 subjects administered physostigmine salicylate in a double-blind, placebo crossover design. In comparison to placebo, the drug caused a significant transient depression in mood, as measured by self- and observer-rated depression scores. In addition, physostigmine significantly increased platelet counts while independently decreasing the maximum velocity (Vmax) of platelet serotonin uptake. Physostigmine administration did not significantly affect the affinity constant (Km) for platelet serotonin uptake. The data are interpreted as being consistent with the postulate that platelet serotonin uptake may be decreased in depressed patients via cholinergic mechanisms.
在一项双盲、安慰剂交叉设计中，对18名服用水杨酸毒扁豆碱的受试者测量了血小板5-羟色胺（5HT）摄取量。与安慰剂相比，通过自我和观察者评定的抑郁评分测量，该药物导致情绪显著短暂低落。此外，毒扁豆碱显著增加血小板计数，同时独立降低血小板5-羟色胺摄取的最大速度（Vmax）。服用毒扁豆碱对血小板5-羟色胺摄取的亲和常数（Km）没有显著影响。这些数据被解释为与以下假设一致，即抑郁症患者的血小板5-羟色胺摄取可能通过胆碱能机制降低。
