短暂自噬抑制引发肿瘤发生：药物性自噬抑制剂的一个危险信号？
Transient Autophagy Inhibition Precipitates Oncogenesis: A Red Flag For Pharmacological Autophagy Inhibitors?
机构信息
Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA; Department of Dermatology, Yale School of Medicine, New Haven, CT, USA; Université de Paris, Paris, France.
Université de Paris, Paris, France; Equipe Labellisée par la Ligue contre le Cancer, INSERM U1138, Centre de Recherche des Cordeliers, Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Institute, Villejuif, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France; Suzhou Institute for Systems Medicine, Chinese Academy of Sciences, Suzhou, China; Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden.
出版信息
Trends Cell Biol. 2020 May;30(5):339-340. doi: 10.1016/j.tcb.2020.02.004. Epub 2020 Feb 27.
Recent findings demonstrate that transient genetic inhibition of autophagy promotes age-associated pathologies in mice. While autophagy restoration effectively counteracts such disorders, it also exacerbates the incidence of various solid and hematological tumors. These data may cast additional shadows on the clinical potential of autophagy inhibition for cancer therapy.
最近的研究结果表明，短暂的自噬基因抑制会促进小鼠与年龄相关的病理变化。虽然自噬的恢复可以有效对抗这些疾病，但它也会增加各种实体瘤和血液系统肿瘤的发病率。这些数据可能会对自噬抑制在癌症治疗中的临床潜力产生更多的负面影响。
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