Ashrafizadeh Milad, Bakhoda Mohammad Reza, Bahmanpour Zahra, Ilkhani Khandan, Zarrabi Ali, Makvandi Pooyan, Khan Haroon, Mazaheri Samaneh, Darvish Maryam, Mirzaei Hamed
Department of Basic Science, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.
Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Front Chem. 2020 Oct 15;8:829. doi: 10.3389/fchem.2020.00829. eCollection 2020.
Pancreatic cancer is the most lethal malignancy of the gastrointestinal tract. Due to its propensity for early local and distant spread, affected patients possess extremely poor prognosis. Currently applied treatments are not effective enough to eradicate all cancer cells, and minimize their migration. Besides, these treatments are associated with adverse effects on normal cells and organs. These therapies are not able to increase the overall survival rate of patients; hence, finding novel adjuvants or alternatives is so essential. Up to now, medicinal herbs were utilized for therapeutic goals. Herbal-based medicine, as traditional biotherapeutics, were employed for cancer treatment. Of them, apigenin, as a bioactive flavonoid that possesses numerous biological properties (e.g., anti-inflammatory and anti-oxidant effects), has shown substantial anticancer activity. It seems that apigenin is capable of suppressing the proliferation of cancer cells the induction of cell cycle arrest and apoptosis. Besides, apigenin inhibits metastasis via down-regulation of matrix metalloproteinases and the Akt signaling pathway. In pancreatic cancer cells, apigenin sensitizes cells in chemotherapy, and affects molecular pathways such as the hypoxia inducible factor (HIF), vascular endothelial growth factor (VEGF), and glucose transporter-1 (GLUT-1). Herein, the biotherapeutic activity of apigenin and its mechanisms toward cancer cells are presented in the current review to shed some light on anti-tumor activity of apigenin in different cancers, with an emphasis on pancreatic cancer.
胰腺癌是胃肠道最致命的恶性肿瘤。由于其易于早期局部和远处转移，受影响患者的预后极差。目前应用的治疗方法不足以有效根除所有癌细胞并减少其迁移。此外，这些治疗方法会对正常细胞和器官产生不良反应。这些疗法无法提高患者的总体生存率；因此，寻找新型佐剂或替代方法至关重要。到目前为止，草药被用于治疗目的。基于草药的药物作为传统生物疗法被用于癌症治疗。其中，芹菜素作为一种具有多种生物学特性（如抗炎和抗氧化作用）的生物活性黄酮类化合物，已显示出显著的抗癌活性。芹菜素似乎能够抑制癌细胞的增殖、诱导细胞周期停滞和凋亡。此外，芹菜素通过下调基质金属蛋白酶和Akt信号通路来抑制转移。在胰腺癌细胞中，芹菜素使细胞对化疗敏感，并影响缺氧诱导因子（HIF）、血管内皮生长因子（VEGF）和葡萄糖转运蛋白-1（GLUT-1）等分子途径。在本综述中，介绍了芹菜素的生物治疗活性及其对癌细胞的作用机制，以阐明芹菜素在不同癌症中的抗肿瘤活性，重点是胰腺癌。
