癌症神经科学新兴领域路线图。
Roadmap for the Emerging Field of Cancer Neuroscience.
机构信息
Departments of Neurology & Neurological Sciences, Pediatrics, Pathology, Neurosurgery, and Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
出版信息
Cell. 2020 Apr 16;181(2):219-222. doi: 10.1016/j.cell.2020.03.034.
Abstract
Mounting evidence indicates that the nervous system plays a central role in cancer pathogenesis. In turn, cancers and cancer therapies can alter nervous system form and function. This Commentary seeks to describe the burgeoning field of "cancer neuroscience" and encourage multidisciplinary collaboration for the study of cancer-nervous system interactions.
摘要
越来越多的证据表明神经系统在癌症发病机制中起着核心作用。反过来，癌症和癌症治疗也可以改变神经系统的形态和功能。本评论旨在描述“癌症神经科学”这一新兴领域，并鼓励开展多学科合作，以研究癌症与神经系统的相互作用。
相似文献
1
Roadmap for the Emerging Field of Cancer Neuroscience.癌症神经科学新兴领域路线图。
Cell. 2020 Apr 16;181(2):219-222. doi: 10.1016/j.cell.2020.03.034.
2
Insights and opportunities at the crossroads of cancer and neuroscience.癌症与神经科学的交叉点上的洞见与机遇。
Nat Cell Biol. 2022 Oct;24(10):1454-1460. doi: 10.1038/s41556-022-00978-w. Epub 2022 Sep 12.
3
Neuroscience of cancer: unraveling the complex interplay between the nervous system, the tumor and the tumor immune microenvironment.癌症神经科学：揭示神经系统、肿瘤与肿瘤免疫微环境之间的复杂相互作用
Mol Cancer. 2025 Jan 17;24(1):24. doi: 10.1186/s12943-024-02219-0.
4
The Case for Neurosurgical Intervention in Cancer Neuroscience.癌症神经科学中神经外科干预的理由。
Neurosurgery. 2025 Jan 1;96(1):10-17. doi: 10.1227/neu.0000000000003039. Epub 2024 Jun 21.
5
Introduction to glyco-neuroscience.糖神经科学导论。
Exp Neurol. 2015 Dec;274(Pt B):89. doi: 10.1016/j.expneurol.2015.11.008.
6
Neuroproteomics: applications in neuroscience and neurology.神经蛋白质组学：在神经科学与神经病学中的应用
Biochim Biophys Acta. 2015 Jul;1854(7):703-4. doi: 10.1016/j.bbapap.2015.04.001. Epub 2015 Apr 6.
7
Cancer neuroscience: State of the field, emerging directions.癌症神经科学：领域现状，新兴方向。
Cell. 2023 Apr 13;186(8):1689-1707. doi: 10.1016/j.cell.2023.02.002.
8
The neuroscience of cancer.癌症的神经科学。
Nature. 2023 Jun;618(7965):467-479. doi: 10.1038/s41586-023-05968-y. Epub 2023 Jun 14.
9
[Cajal and neuroscience in the eve of the third millenium].[卡哈尔与第三个千年前夕的神经科学]
An R Acad Nac Med (Madr). 2000;117(3):451-63; discussion 464-7.
10
An Overview of the Molecular Cues and Their Intracellular Signaling Shared by Cancer and the Nervous System: From Neurotransmitters to Synaptic Proteins, Anatomy of an All-Inclusive Cooperation.癌症与神经系统共享的分子线索及其细胞内信号概述：从神经递质到突触蛋白，全面合作的解剖结构。
Int J Mol Sci. 2022 Nov 24;23(23):14695. doi: 10.3390/ijms232314695.
引用本文的文献
1
Colorectal cancer cells hijack a brain-gut polysynaptic circuit from the lateral septum to enteric neurons to sustain tumor growth.结肠直肠癌细胞劫持了一条从外侧隔到肠神经元的脑-肠多突触回路，以维持肿瘤生长。
Nat Cancer. 2025 Aug 21. doi: 10.1038/s43018-025-01033-x.
2
Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy.癌症诱导的神经损伤促进对抗PD-1疗法的耐药性。
Nature. 2025 Aug 20. doi: 10.1038/s41586-025-09370-8.
3
Neuroligin-3 interaction with CSPG4 regulates normal and malignant glial precursors through PIEZO1.神经连接蛋白-3与CSPG4的相互作用通过PIEZO1调节正常和恶性神经胶质前体细胞。
bioRxiv. 2025 Jul 17:2025.07.12.664340. doi: 10.1101/2025.07.12.664340.
4
Causal Association Between Immune Cell Traits and Risk of Multiple Malignant and Nonmalignant CNS Diseases: A Mendelian Randomization and Single-Cell Transcriptomic Analysis.免疫细胞特征与多种恶性和非恶性中枢神经系统疾病风险之间的因果关联：孟德尔随机化和单细胞转录组分析
Brain Behav. 2025 Aug;15(8):e70632. doi: 10.1002/brb3.70632.
5
Exploring causal relationships between brain imaging-derived phenotypes and ovarian cancer risk: a bidirectional Mendelian randomization.探索脑成像衍生表型与卵巢癌风险之间的因果关系：双向孟德尔随机化研究
J Ovarian Res. 2025 Aug 1;18(1):173. doi: 10.1186/s13048-025-01733-z.
6
Hijacking homeostasis: the brain-body neural circuitry in tumor pathogenesis and emerging therapeutic frontiers.劫持体内平衡：肿瘤发病机制中的脑-体神经回路及新兴治疗前沿
Mol Cancer. 2025 Jul 25;24(1):206. doi: 10.1186/s12943-025-02396-6.
7
The regulation of reporter transgene expression for diverse biological imaging applications.用于多种生物成像应用的报告基因转基因表达调控。
Npj Imaging. 2025 Mar 4;3(1):9. doi: 10.1038/s44303-025-00070-6.
8
Metabotropic glutamate receptor 4-mediated glutamatfergic signaling reshapes the tumor microenvironment by regulating dendritic cell maturation.代谢型谷氨酸受体4介导的谷氨酸能信号通过调节树突状细胞成熟来重塑肿瘤微环境。
Nat Commun. 2025 Jul 1;16(1):5874. doi: 10.1038/s41467-025-60922-y.
9
Tumor-infiltrating nerves: unraveling the role of cancer neuroscience in tumorigenesis, disease progression, and emerging therapies.肿瘤浸润神经：揭示癌症神经科学在肿瘤发生、疾病进展及新兴疗法中的作用
Discov Oncol. 2025 Jul 1;16(1):1209. doi: 10.1007/s12672-025-02827-2.
10
Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling.胆碱能神经元活动通过毒蕈碱信号传导促进弥漫性中线胶质瘤生长。
Cell. 2025 Jun 19. doi: 10.1016/j.cell.2025.05.031.
本文引用的文献
1
PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis.PIK3CA 变异体在胶质瘤发生过程中选择性地引发大脑过度活跃。
Nature. 2020 Feb;578(7793):166-171. doi: 10.1038/s41586-020-1952-2. Epub 2020 Jan 29.
2
Electrical and synaptic integration of glioma into neural circuits.胶质瘤对神经回路的电和突触整合。
Nature. 2019 Sep;573(7775):539-545. doi: 10.1038/s41586-019-1563-y. Epub 2019 Sep 18.
3
Glutamatergic synaptic input to glioma cells drives brain tumour progression.谷氨酸能突触输入到神经胶质细胞瘤驱动脑肿瘤的进展。
Nature. 2019 Sep;573(7775):532-538. doi: 10.1038/s41586-019-1564-x. Epub 2019 Sep 18.
4
Synaptic proximity enables NMDAR signalling to promote brain metastasis.突触接近使 NMDAR 信号能够促进脑转移。
Nature. 2019 Sep;573(7775):526-531. doi: 10.1038/s41586-019-1576-6. Epub 2019 Sep 18.
5
Progenitors from the central nervous system drive neurogenesis in cancer.中枢神经系统祖细胞驱动癌症中的神经发生。
Nature. 2019 May;569(7758):672-678. doi: 10.1038/s41586-019-1219-y. Epub 2019 May 15.
6
Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment.甲氨蝶呤化疗诱导持续的三胶质细胞失调，是化疗相关性认知障碍的基础。
Cell. 2019 Jan 10;176(1-2):43-55.e13. doi: 10.1016/j.cell.2018.10.049. Epub 2018 Dec 6.
7
Cholinergic Signaling via Muscarinic Receptors Directly and Indirectly Suppresses Pancreatic Tumorigenesis and Cancer Stemness.乙酰胆碱通过毒蕈碱受体直接和间接抑制胰腺肿瘤发生和癌症干性。
Cancer Discov. 2018 Nov;8(11):1458-1473. doi: 10.1158/2159-8290.CD-18-0046. Epub 2018 Sep 5.
8
A Role for Hypocretin/Orexin in Metabolic and Sleep Abnormalities in a Mouse Model of Non-metastatic Breast Cancer.下丘脑食欲素/食欲肽在非转移性乳腺癌小鼠模型代谢和睡眠异常中的作用。
Cell Metab. 2018 Jul 3;28(1):118-129.e5. doi: 10.1016/j.cmet.2018.04.021. Epub 2018 May 24.
9
Adrenergic nerves activate an angio-metabolic switch in prostate cancer.肾上腺素能神经激活前列腺癌中的血管代谢开关。
Science. 2017 Oct 20;358(6361):321-326. doi: 10.1126/science.aah5072.
10
Paclitaxel Reduces Axonal Bclw to Initiate IPR1-Dependent Axon Degeneration.紫杉醇降低轴突Bclw以启动IPR1依赖性轴突退化。
Neuron. 2017 Oct 11;96(2):373-386.e6. doi: 10.1016/j.neuron.2017.09.034.
Zotero 插件