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颅骨穹窿重塑术与内镜下缝扎切除术治疗单侧人字缝早闭的对比分析

Comparative analysis of cranial vault remodeling versus endoscopic suturectomy in the treatment of unilateral lambdoid craniosynostosis.

作者信息

Rattani Abbas, Riordan Coleman P, Meara John G, Proctor Mark R

机构信息

1Program in Global Surgery and Social Change, Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts.

2Department of Surgery, Rush University Medical Center, Chicago, Illinois; and.

出版信息

J Neurosurg Pediatr. 2020 Apr 17;26(2):105-112. doi: 10.3171/2020.2.PEDS19522. Print 2020 Aug 1.

Abstract

OBJECTIVE

Unilateral lambdoid synostosis is the premature fusion of a lambdoid suture or sutures and represents the least common form of craniosynostosis, occurring in 1 in 40,000 births. Cranial vault remodeling (CVR) and endoscopic suturectomy with helmet therapy (ES) are surgical approaches that are used to allow for normal brain growth and improved craniofacial symmetry. The authors conducted a comparative outcomes analysis of patients with lambdoid synostosis undergoing either CVR or ES.

METHODS

The authors conducted a retrospective consecutive cohort study of patients with nonsyndromic lambdoid synostosis who underwent surgical correction identified from a single-institution database of patients with craniosynostosis seen between 2000 and 2018. Cranial growth was measured in head circumference percentile and z score.

RESULTS

Nineteen patients (8 female and 11 male) with isolated unilateral lambdoid synostosis were identified (8 right and 11 left). Six underwent CVR and 13 underwent ES. No statistically significant differences were noted between surgical groups with respect to suture laterality, the patient's sex, and length of follow-up. Patients treated with ES presented and underwent surgery at a younger age than those treated with CVR (p = 0.0002 and p = 0.0001, respectively). Operating and anesthesia time, estimated blood loss, and ICU and total hospital days were significantly lower in ES (all p < 0.05). No significant differences were observed in pre- and postoperative head circumference percentiles or z scores between groups up to 36 months postoperatively. No patients required reoperation as of last follow-up.

CONCLUSIONS

Endoscopic management of lambdoid synostosis is safe, efficient, and efficacious in terms of intraoperative and long-term cranial growth outcomes when compared to CVR. The authors recommend this minimally invasive approach as an option for correction of lambdoid synostosis in patients presenting early in their course.

摘要

目的

单侧人字缝早闭是指一条或多条人字缝过早融合,是颅缝早闭最不常见的形式,发病率为40000例活产儿中有1例。颅骨重塑(CVR)和内镜下缝骨切除术联合头盔治疗(ES)是用于促进大脑正常生长和改善颅面对称性的手术方法。作者对接受CVR或ES治疗的人字缝早闭患者进行了对比疗效分析。

方法

作者对2000年至2018年间从单一机构颅缝早闭患者数据库中识别出的非综合征性人字缝早闭并接受手术矫正的患者进行了回顾性连续队列研究。通过头围百分位数和z评分来测量颅骨生长情况。

结果

共识别出19例孤立性单侧人字缝早闭患者(8例女性和11例男性)(8例右侧,11例左侧)。6例接受CVR,13例接受ES。手术组在缝骨位置、患者性别和随访时间方面未观察到统计学上的显著差异。接受ES治疗的患者比接受CVR治疗的患者就诊和手术时年龄更小(分别为p = 0.0002和p = 0.0001)。ES组的手术和麻醉时间、估计失血量、重症监护病房(ICU)住院天数和总住院天数均显著更低(所有p < 0.05)。术后36个月内,两组术前和术后的头围百分位数或z评分均未观察到显著差异。截至最后一次随访,无患者需要再次手术。

结论

与人字缝早闭的CVR治疗相比,ES治疗在术中及长期颅骨生长结果方面是安全、高效且有效的。作者推荐这种微创方法作为病程早期患者人字缝早闭矫正的一种选择。

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