Respiratory Medicine, Hospital Professor Fernando Fonseca (HFF), Lisbon, Portugal.
School of Medicine, University of Dundee, Dundee, UK.
Thorax. 2020 Jul;75(7):592-593. doi: 10.1136/thoraxjnl-2019-214195. Epub 2020 Apr 17.
Alpha-1 antitrypsin deficiency (AATD) is a cause of bronchiectasis. Guidelines for bronchiectasis from the British Thoracic Society do not recommend to routinely test patients for AATD. In contrast, guidelines for AATD recommend routine screening. This contradiction, in part, results from the lack of data from large studies performing comprehensive screening. We screened 1600 patients with bronchiectasis at two centres in the UK from 2012 to 2016. In total, only eight individuals with AATD were identified representing 0.5% of the overall population. We conclude that routine screening for AATD in bronchiectasis in the UK has a low rate of detection. Further studies are required in different geographical regions, which may have a higher prevalence of AATD.
α-1 抗胰蛋白酶缺乏症（AATD）是支气管扩张症的一个病因。英国胸科学会的支气管扩张症指南不建议对患者常规检测 AATD。相反，AATD 指南建议进行常规筛查。这种矛盾在一定程度上是由于缺乏对大规模进行全面筛查的研究的数据所致。我们于 2012 年至 2016 年在英国的两个中心筛查了 1600 名支气管扩张症患者。总共只发现了 8 例 AATD 患者，占总人口的 0.5%。我们得出结论，在英国，对支气管扩张症患者进行 AATD 的常规筛查检出率较低。需要在具有更高 AATD 患病率的不同地理区域开展进一步的研究。
