Agriculture & Agri-Food Canada, Guelph Research & Development Center, 93 Stone Road W, Guelph, ON, N1G5C9, Canada.
Mol Biol Rep. 2020 May;47(5):4037-4046. doi: 10.1007/s11033-020-05389-4. Epub 2020 Apr 17.
With the advent of the multidrug-resistant era, many opportunistic pathogens including the species Acinetobacter baumannii have gained prominence and pose a major global threat to clinical health care. Pathogenicity in bacteria is genetically regulated by a complex network of transcription and virulence factors and a brief overview of the major investigations on comprehending these processes over the past few decades in A. baumanni are compiled here. Many investigators have employed genome sequencing techniques to identify the regions that contribute to antibiotic resistance and comparative genomics to study sequence similarities to understand evolutionary trends of resistance gene transfers between isolates. A summary of these studies given here provides an insight into the invasion and successful colonization of the species. The individual roles played by different genes, regulators & promoters, enzymes, metal ions as well as mobile elements in influencing antibiotic resistance are briefly discussed. Precautionary measures and prospects for developing future strategies by exploring promising new research targets in effective control of multidrug resistant A. baumannii are also analyzed.
随着多药耐药时代的到来，许多机会性病原体，包括鲍曼不动杆菌等物种，已经引起了人们的关注，并对临床医疗保健构成了重大的全球威胁。细菌的致病性受转录和毒力因子的复杂网络基因调控，本文简要综述了过去几十年中在鲍曼不动杆菌中对这些过程的主要研究。许多研究人员采用基因组测序技术来确定有助于抗生素耐药性的区域，并进行比较基因组学研究以研究序列相似性，从而了解耐药基因在分离株之间转移的进化趋势。这里给出的这些研究的摘要提供了对该物种入侵和成功定植的深入了解。简要讨论了不同基因、调节剂和启动子、酶、金属离子以及移动元件在影响抗生素耐药性方面的作用。还分析了通过探索有前途的新研究目标来预防措施和开发未来策略，以有效控制多药耐药鲍曼不动杆菌。
