Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Mol Biol Rep. 2024 Oct 8;51(1):1044. doi: 10.1007/s11033-024-09979-4.
In the current era of antibiotic resistance, researchers are exploring alternative ways to treat bacterial infections that are resistant to multiple drugs. Acinetobacter baumannii (A. baumannii) is a bacterium that is commonly encountered in clinical settings and is known to be resistant to several drugs. Due to the increase in drug-resistant infections caused by this bacteria, there is an urgent need to investigate alternative treatment options such as phage therapy and combination therapy. Despite the success of phages in some cases, there are some limitations in their clinical application that can be overcome by combining phages with other substrates such as nanoparticles to improve their function. The integration of nanotechnology with phage therapy against A. baumannii promises to overcome antibiotic resistance. By exploiting the targeted delivery and controlled release capabilities of nanoparticles, we can enhance the therapeutic potential of phages while minimizing their limitations. Continued research in this field will undoubtedly pave the way for more effective and precise treatments against A. baumannii infections and provide hope in the fight against antibiotic-resistant bacteria.
在当前抗生素耐药的时代，研究人员正在探索治疗对多种药物耐药的细菌感染的替代方法。鲍曼不动杆菌（A.baumannii）是一种常见于临床环境中的细菌，已知对多种药物具有耐药性。由于这种细菌引起的耐药性感染增加，因此迫切需要研究替代治疗方法，如噬菌体治疗和联合治疗。尽管噬菌体在某些情况下取得了成功，但在其临床应用中仍存在一些限制，可通过将噬菌体与纳米粒子等其他底物结合来克服这些限制，以提高其功能。将纳米技术与噬菌体联合用于治疗鲍曼不动杆菌有望克服抗生素耐药性。通过利用纳米粒子的靶向递药和控制释放能力，我们可以在最小化其局限性的同时提高噬菌体的治疗潜力。该领域的持续研究无疑将为对抗鲍曼不动杆菌感染提供更有效和精确的治疗方法铺平道路，并为对抗抗生素耐药菌带来希望。
