Zoology Department, Faculty of Science, Cairo University Giza Egypt, Giza, Egypt.
Zoology Department, Faculty of Science, Damietta University New Damietta Egypt, Damieta, Egypt.
Environ Sci Pollut Res Int. 2020 Jul;27(19):23950-23962. doi: 10.1007/s11356-020-08137-0. Epub 2020 Apr 17.
Increasing the uses of molybdenum (Mo) nanoparticles in a wide range of applications including food, industry, and medicine, resulted in increased human exposure and necessitated the study of their toxic effects. However, almost no studies are available on their genotoxic effects, especially on pregnant females and their fetuses. Therefore, this study was undertaken to estimate the possible induction of genotoxicity and fetal abnormalities, especially fetal malformations and skeletal abnormalities by Mo nanoparticle administration in mice. Oral administration of Mo nanoparticles resulted in significant decreases in the maternal body weight, the number and length of fetuses as well as skeletal abnormalities mainly less ossification and less chondrification. Administration of Mo nanoparticles also caused DNA damage induction which elevated the expression levels of p53, the vital gene in maintaining the genomic stability and cell differentiation in both maternal and fetus tissues. Similarly, the expression levels of E-Cad and N-Cad genes that control skeleton development have also been increased in the tissues of female mice administered Mo nanoparticles and their fetuses. Thus, we concluded that oral administration of Mo nanoparticles induced genotoxic effects and fetal abnormalities that necessitated further studies on the possible toxic effects of Mo nanoparticles.
钼纳米粒子在食品、工业和医学等广泛应用中的使用不断增加，导致人类接触量增加，因此有必要研究其毒性作用。然而，几乎没有关于其遗传毒性作用的研究，特别是关于孕妇及其胎儿的研究。因此，本研究旨在评估钼纳米粒子给药是否可能诱导遗传毒性和胎儿异常，特别是胎儿畸形和骨骼异常。给小鼠口服钼纳米粒子导致母体体重、胎儿数量和长度以及骨骼异常（主要是骨化减少和软骨化减少）显著下降。钼纳米粒子给药还导致 DNA 损伤诱导，从而增加了 p53 的表达水平，p53 是维持基因组稳定性和细胞分化的重要基因，存在于母体和胎儿组织中。同样，控制骨骼发育的 E-Cad 和 N-Cad 基因的表达水平在给予钼纳米粒子的雌性小鼠及其胎儿的组织中也增加了。因此，我们得出结论，口服钼纳米粒子诱导遗传毒性作用和胎儿异常，这需要进一步研究钼纳米粒子的可能毒性作用。
