Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, USA.
Laboratory of Tumor and Development Biology, GIGA-Cancer, University of Liège, Liège, Belgium.
Adv Exp Med Biol. 2020;1220:11-34. doi: 10.1007/978-3-030-35805-1_2.
Circulating tumor cells offer an unprecedented window into the metastatic cascade, and to some extent can be considered as intermediates in the process of metastasis. They exhibit dynamic oscillations in epithelial to mesenchymal plasticity and provide important opportunities for prognosis, therapy response monitoring, and targeting of metastatic disease. In this manuscript, we review the involvement of epithelial-mesenchymal plasticity in the early steps of metastasis and what we have learned about its contribution to genomic instability and genetic diversity, tumor progression and therapeutic responses using cell culture, mouse models and circulating tumor cells enriched from patients.
循环肿瘤细胞为转移级联过程提供了一个前所未有的窗口，在某种程度上可以被视为转移过程中的中间产物。它们表现出上皮-间充质可塑性的动态波动，并为预后、治疗反应监测和转移性疾病的靶向治疗提供了重要机会。在本文中，我们综述了上皮-间充质可塑性在转移早期步骤中的作用，以及我们通过细胞培养、小鼠模型和从患者中富集的循环肿瘤细胞了解到的其对基因组不稳定性和遗传多样性、肿瘤进展和治疗反应的贡献。
