Koyama T, Araiso T
Section of Physiology, Hokkaido University, Sapporo, Japan.
J Nutr Sci Vitaminol (Tokyo). 1988 Oct;34(5):449-57. doi: 10.3177/jnsv.34.449.
The effects of alpha-tocopherol-nicotinate on the microdynamic parameters, membrane viscosity, and wobbling angle of phospholipid molecules of healthy human erythrocyte membranes were studied with a nanosecond time-resolved fluorometer. The incorporation of alpha-tocopherol was achieved by oral administration of alpha-tocopherol-nicotinate for one month with dosage of 400 mg/day. The increase in alpha-tocopherol concentration in erythrocytes was confirmed in two subjects. The membrane viscosity in seven healthy subjects decreased significantly from 1.015 +/- 0.137 to 0.888 +/- 0.133 mPa.s. But no changes in the wobbling angle of phospholipid molecules were observed.
用纳秒时间分辨荧光计研究了α-生育酚烟酸酯对健康人红细胞膜的微动力学参数、膜粘度和磷脂分子摆动角的影响。通过口服α-生育酚烟酸酯，剂量为400毫克/天，持续一个月来实现α-生育酚的掺入。在两名受试者中证实了红细胞中α-生育酚浓度的增加。七名健康受试者的膜粘度从1.015±0.137显著降低至0.888±0.133毫帕·秒。但未观察到磷脂分子摆动角的变化。
