Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Guangzhou, PR China.
Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou, PR China.
Indoor Air. 2020 Sep;30(5):816-826. doi: 10.1111/ina.12677. Epub 2020 May 1.
Recent studies reveal that the microbial diversity and composition in the respiratory tract are related to the susceptibility, development, and progression of respiratory infections. Indoor microorganisms can transmit into the respiratory tract through breathing, but their role in infections is unclear. Here, we present the first association study between the indoor microbiome and respiratory infections. In total, 357 students living in 86 dormitory rooms in Shanxi University were randomly selected to survey symptoms of infections. Settled air dust was collected to characterize bacterial compositions by 16S rRNA sequencing. The overall microbial richness was not associated with respiratory infections, but microorganisms from specific phylogenetic classes showed various associations. Taxa richness and abundance of Actinobacteria were protectively associated with infections (P < .05). The abundance of several genera in Gammaproteobacteria, including Haemophilus, Klebsiella, Buttiauxella, and Raoultella, was positively associated with infections (P < .005). The role of these microorganisms was consistent with previous human microbiota studies. Building age was associated with the overall microbial composition variation in dormitories and negatively associated with three potential risk genera in Proteobacteria (P < .05). The weight of vacuum dust was positively associated with a protective genus, Micrococcus in Actinobacteria (P < .05).
最近的研究表明，呼吸道中的微生物多样性和组成与呼吸道感染的易感性、发展和进展有关。室内微生物可以通过呼吸传播到呼吸道，但它们在感染中的作用尚不清楚。在这里，我们首次进行了室内微生物组与呼吸道感染之间的关联研究。我们随机选择了山西大学 86 间宿舍的 357 名学生进行感染症状调查。采集沉降空气尘埃，通过 16S rRNA 测序来描述细菌组成。总体微生物丰富度与呼吸道感染无关，但来自特定系统发育类群的微生物表现出不同的关联。放线菌的分类丰富度和丰度与感染呈保护相关（P<.05）。γ变形菌目中包括嗜血杆菌、克雷伯菌、布氏杆菌和罗尔氏菌在内的几个属的丰度与感染呈正相关（P<.005）。这些微生物的作用与先前的人类微生物组研究一致。建筑年代与宿舍内整体微生物组成的变化有关，与变形菌门中三个潜在的风险属呈负相关（P<.05）。真空尘埃的重量与放线菌中的保护性属微球菌呈正相关（P<.05）。
