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术后克罗恩病的管理。

Postoperative Crohn's disease management.

机构信息

Division of Gastroenterology and Hepatology, Department of Medicine.

Multidisciplinary Center for Inflammatory Bowel Diseases.

出版信息

Curr Opin Gastroenterol. 2020 Jul;36(4):277-283. doi: 10.1097/MOG.0000000000000638.

DOI:10.1097/MOG.0000000000000638
PMID:32304384
Abstract

PURPOSE OF REVIEW

Despite multiple advances in the medical treatment of Crohn's disease, it is recognized that a significant proportion of patients will ultimately require surgical resection at some point during their disease course. This review focuses on the postoperative management of patients with Crohn's disease, with the goal of preventing endoscopic and clinical recurrence, and future surgery.

RECENT FINDINGS

Surgery is an integral part of the multidisciplinary approach to the management of patients with Crohn's disease. Recent literature and guidelines have focused on a standardized and evidence-based approach to the management of patients in the postoperative setting. This approach should utilize risk stratification at the time of surgery, initiation of appropriate therapy among high-risk patients, and objective evaluation in the postoperative period, including ileocolonoscopy at 6-12 months after a surgical resection.

SUMMARY

A standardized approach to the postoperative management of patients with Crohn's disease is critical. Identifying those patients at high-risk for endoscopic and clinical recurrence is essential, as these patients will likely require early medical therapy. While novel objective assessments are emerging, all patients should undergo ileocolonoscopy at 6-12 months and further decision making should be based on the presence of endoscopic recurrence.

摘要

目的综述

尽管在克罗恩病的医学治疗方面取得了多项进展,但人们认识到,在疾病过程中的某个阶段,相当一部分患者最终将需要手术切除。本综述重点介绍克罗恩病患者的术后管理,旨在预防内镜和临床复发以及未来的手术。

最近的发现

手术是克罗恩病患者多学科治疗方法的一个组成部分。最近的文献和指南侧重于对术后患者进行标准化和基于证据的管理方法。这种方法应在手术时进行风险分层,在高危患者中开始适当的治疗,并在术后进行客观评估,包括在手术切除后 6-12 个月进行回结肠镜检查。

总结

对克罗恩病患者进行标准化的术后管理至关重要。确定那些内镜和临床复发风险高的患者至关重要,因为这些患者可能需要早期药物治疗。虽然新的客观评估方法正在出现,但所有患者均应在 6-12 个月时进行回结肠镜检查,进一步的决策应基于内镜复发的情况。

相似文献

1
Postoperative Crohn's disease management.术后克罗恩病的管理。
Curr Opin Gastroenterol. 2020 Jul;36(4):277-283. doi: 10.1097/MOG.0000000000000638.
2
Preventive therapy in postoperative Crohn's disease.术后克罗恩病的预防治疗。
Curr Opin Gastroenterol. 2010 Jul;26(4):337-43. doi: 10.1097/MOG.0b013e328338f724.
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The evolving management of postoperative Crohn's disease.术后克罗恩病的治疗进展。
Expert Rev Gastroenterol Hepatol. 2012 Sep;6(5):637-48. doi: 10.1586/egh.12.45.
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[Problems related to postoperative clinical relapse and endoscopic recurrence in Crohn's disease].[克罗恩病术后临床复发与内镜复发相关问题]
Recenti Prog Med. 2009 Oct;100(10):469-78.
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Colonoscopy-guided therapy for the prevention of post-operative recurrence of Crohn's disease.结肠镜引导下治疗预防克罗恩病术后复发
Cochrane Database Syst Rev. 2020 Aug 3;8(8):CD012328. doi: 10.1002/14651858.CD012328.pub2.
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Management of postoperative Crohn's disease.克罗恩病术后管理
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Clinical Update on the Prevention and Management of Postoperative Crohn's Disease Recurrence.临床更新:预防和管理术后克罗恩病复发。
Curr Gastroenterol Rep. 2024 Feb;26(2):41-52. doi: 10.1007/s11894-023-00911-7. Epub 2024 Jan 16.
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A Practical Approach to Preventing Postoperative Recurrence in Crohn's Disease.预防克罗恩病术后复发的实用方法
Curr Gastroenterol Rep. 2016 May;18(5):25. doi: 10.1007/s11894-016-0499-8.
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Factors affecting the incidence of early endoscopic recurrence after ileocolonic resection for Crohn's disease: a multicentre observational study.克罗恩病回结肠切除术后早期内镜复发发生率的影响因素:一项多中心观察性研究
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Fecal calprotectin one year after ileocaecal resection for Crohn's disease--a comparison with findings at ileocolonoscopy.克罗恩病回盲部切除术后一年的粪便钙卫蛋白——与回结肠镜检查结果的比较
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引用本文的文献

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Surgical and non-surgical risk factors affecting the insufficiency of ileocolic anastomosis after first-time surgery in Crohn's disease patients.影响克罗恩病患者首次手术后回结肠吻合口功能不全的手术和非手术风险因素。
World J Gastrointest Surg. 2024 Oct 27;16(10):3253-3260. doi: 10.4240/wjgs.v16.i10.3253.
2
Impact of different anastomosis methods on post-recurrence after intestinal resection for Crohn's disease: A meta-analysis.不同吻合方法对克罗恩病肠切除术后复发的影响:一项荟萃分析。
World J Gastrointest Surg. 2024 Apr 27;16(4):1165-1175. doi: 10.4240/wjgs.v16.i4.1165.
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Anti-TNF Agents and New Biological Agents (Vedolizumab and Ustekinumab) in the Prevention and Treatment of Postoperative Recurrence After Surgery in Crohn's Disease.
抗 TNF 制剂和新型生物制剂(维得利珠单抗和乌司奴单抗)在克罗恩病术后预防和治疗复发中的作用。
Drugs. 2023 Sep;83(13):1179-1205. doi: 10.1007/s40265-023-01916-2. Epub 2023 Jul 28.
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Rate and risk factors of postoperative endoscopic recurrence of moderate- to high-risk Crohn's disease patients - A real-world experience from a Middle Eastern cohort.中高危克罗恩病患者术后内镜复发率及危险因素——来自中东队列的真实世界经验
Saudi J Gastroenterol. 2022 May-Jun;28(3):201-208. doi: 10.4103/sjg.sjg_499_21.