Department of Neonatology, Chongqing University Three Gorges Hospital, Department of Neonatology, Chongqing Three Gorges Central Hospital, 165 Xin Cheng Road, Wanzhou District, Chongqing 404000, China.
Department of Neonatology, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Children's Hospital of Chongqing Medical University, No.136 Zhongshan Er Road, Yuzhong District, Chongqing 400014, China.
J Infect Public Health. 2020 May;13(5):818-820. doi: 10.1016/j.jiph.2020.04.004. Epub 2020 Apr 11.
As the 2019 novel coronavirus disease (COVID-19) rapidly spread across China and to more than 70 countries, an increasing number of pregnant women were affected. The vertical transmission potential of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is of great concern to the obstetrics, neonatologists, and public health agencies. Though some studies indicated the risk of vertical transmission is low, few cases have been reported with comprehensive serial tests from multiple specimens. In this case, a female preterm infant was born to a mother with confirmed COVID-19. She presented with mild respiratory distress and received general management and a short period of nasal continuous positive airway pressure support. During her stay at the hospital, a series of SARS-CoV-2 nucleic test from her throat and anal swab, serum, bronchoalveolar lavage fluid, and urine were negative. The nucleic acid test from the mother's amniotic fluid, vaginal secretions, cord blood, placenta, serum, anal swab, and breast milk were also negative. The most comprehensively tested case reported to date confirmed that the vertical transmission of COVID is unlikely, but still, more evidence is needed.
随着 2019 年新型冠状病毒病（COVID-19）在中国迅速蔓延，并传播到 70 多个国家，越来越多的孕妇受到感染。严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）的垂直传播潜力引起了产科医生、新生儿科医生和公共卫生机构的极大关注。尽管一些研究表明垂直传播的风险较低，但很少有病例报告进行了来自多个样本的全面连续检测。在本例中，一名患有确诊 COVID-19 的母亲分娩了一名早产女婴。她表现出轻度呼吸窘迫，并接受了一般治疗和短期鼻持续气道正压通气支持。在住院期间，对她的咽喉和肛门拭子、血清、肺泡灌洗液和尿液进行了一系列 SARS-CoV-2 核酸检测，结果均为阴性。对母亲的羊水、阴道分泌物、脐血、胎盘、血清、肛门拭子和母乳进行的核酸检测结果也均为阴性。迄今为止报告的检测最全面的病例证实 COVID 的垂直传播不太可能，但仍需要更多证据。
