新冠病毒感染嗅觉丧失的特征。
Features of anosmia in COVID-19.
机构信息
Infectious Diseases Department, Nord Franche-Comté Hospital, 90400 Trévenans, France.
Infectious Diseases Department, Nord Franche-Comté Hospital, 90400 Trévenans, France.
出版信息
Med Mal Infect. 2020 Aug;50(5):436-439. doi: 10.1016/j.medmal.2020.04.006. Epub 2020 Apr 17.
BACKGROUND
Medical publications about anosmia with COVID-19 are scarce. We aimed to describe the prevalence and features of anosmia in COVID-19 patients.
METHODS
We retrospectively included COVID-19 patients with anosmia between March 1st and March 17th, 2020. We used SARS-CoV-2 real time PCR in respiratory samples to confirm the cases.
RESULTS
Fifty-four of 114 patients (47%) with confirmed COVID-19 reported anosmia. Mean age of the 54 patients was 47 (±16) years; 67% were females and 37% were hospitalised. The median Charlson comorbidity index was 0.70 (±1.6 [0-7]). Forty-six patients (85%) had dysgeusia and 28% presented with pneumonia. Anosmia began 4.4 (±1.9 [1-8]) days after infection onset. The mean duration of anosmia was 8.9 (±6.3 [1-21]) days and 98% of patients recovered within 28 days.
CONCLUSIONS
Anosmia was present in half of our European COVID-19 patients and was often associated with dysgeusia.
背景
有关 COVID-19 伴嗅觉丧失的医学文献很少。我们旨在描述 COVID-19 患者嗅觉丧失的患病率和特征。
方法
我们回顾性纳入了 2020 年 3 月 1 日至 3 月 17 日期间患有嗅觉丧失的 COVID-19 患者。我们使用 SARS-CoV-2 实时 PCR 在呼吸道样本中确认病例。
结果
在 114 例确诊 COVID-19 的患者中，有 54 例（47%）报告有嗅觉丧失。54 例患者的平均年龄为 47（±16）岁；67%为女性，37%住院。Charlson 合并症指数中位数为 0.70（±1.6 [0-7]）。46 例（85%）有味觉障碍，28%出现肺炎。嗅觉丧失在感染后 4.4（±1.9 [1-8]）天开始。嗅觉丧失的平均持续时间为 8.9（±6.3 [1-21]）天，98%的患者在 28 天内恢复。
结论
在我们的欧洲 COVID-19 患者中，有一半存在嗅觉丧失，并且常伴有味觉障碍。
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