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江苏省输入性新型冠状病毒肺炎(COVID-19)病例的临床特征:一项多中心描述性研究。

Clinical Characteristics of Imported Cases of Coronavirus Disease 2019 (COVID-19) in Jiangsu Province: A Multicenter Descriptive Study.

机构信息

State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Department of Laboratory Medicine, The First People's Hospital of Yancheng City, Yancheng, China.

出版信息

Clin Infect Dis. 2020 Jul 28;71(15):706-712. doi: 10.1093/cid/ciaa199.

Abstract

BACKGROUND

We aimed to report the clinical characteristics of imported cases of coronavirus disease 2019 (COVID-19) in Jiangsu Province.

METHODS

We retrospectively investigated the clinical, imaging, and laboratory characteristics of confirmed cases of COVID-19 with World Health Organization interim guidance in 3 grade IIIA hospitals of Jiangsu from 22 January to 14 February 2020. Real-time RT-PCR was used to detect the new coronavirus in respiratory samples.

RESULTS

Of the 80 patients infected with COVID-19, 41 were female, with a median age of 46.1 years. Except for 3 severe patients, the rest of the 77 patients exhibited mild or moderate symptoms. Nine patients were unconfirmed until a third nucleic acid test; 38 cases had a history of chronic diseases. The main clinical manifestations of the patients were fever and cough, which accounted for 63 (78.75%) and 51 (63.75%) cases, respectively. Only 3 patients (3.75%) showed liver dysfunction. Imaging examination showed that 55 patients (68.75%) showed abnormal density shadow and 25 cases (31.25%) had no abnormal density shadow in the parenchyma of both lungs. Currently, 21 cases have been discharged from the hospital, and no patient died. The average length of stay for discharged patients was 8 days.

CONCLUSIONS

Compared with the cases in Wuhan, the cases in Jiangsu exhibited mild or moderate symptoms and no obvious gender susceptibility. The proportion of patients having liver dysfunction and abnormal CT imaging was relatively lower than that in Wuhan. Notably, infected patients may be falsely excluded based on 2 consecutively negative respiratory pathogenic nucleic acid test results.

摘要

背景

本研究旨在报告江苏省输入性新型冠状病毒病(COVID-19)病例的临床特征。

方法

我们回顾性调查了 2020 年 1 月 22 日至 2 月 14 日江苏省 3 家 3A 级医院根据世界卫生组织临时指南确诊的 COVID-19 患者的临床、影像学和实验室特征。采用实时 RT-PCR 检测呼吸道样本中的新型冠状病毒。

结果

80 例 COVID-19 感染患者中,41 例为女性,中位年龄 46.1 岁。除 3 例重症患者外,其余 77 例患者症状均为轻至中度。9 例患者在第三次核酸检测后才得到确诊;38 例有慢性病病史。患者的主要临床表现为发热和咳嗽,分别占 63(78.75%)和 51(63.75%)例。仅 3 例(3.75%)患者出现肝功能异常。影像学检查显示,55 例(68.75%)患者肺部实质出现异常密度影,25 例(31.25%)患者肺部实质无异常密度影。目前,21 例患者已出院,无患者死亡。出院患者的平均住院时间为 8 天。

结论

与武汉病例相比,江苏病例症状较轻或为中度,无明显性别易感性。肝功能异常和 CT 影像学异常的患者比例相对较低。值得注意的是,连续两次呼吸道病原核酸检测阴性可能导致患者被错误排除。

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