Department of Psychiatry and Neurochemistry at Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Acta Psychiatr Scand. 2020 Jun;141(6):534-540. doi: 10.1111/acps.13174. Epub 2020 May 7.
To investigate external factors that trigger manic and hypomanic relapses and how this is associated with personality and clinical outcome measured as number of affective episodes over a 7-year period.
This is a prospective cohort study of 204 meticulously characterized Swedish bipolar disorder patients. Personality was evaluated at baseline using the Swedish universities Scales of Personality in 170 patients, and 90 patients were followed up after approximately 7 years in order to evaluate clinical outcomes.
We found that 44% of the patients reported trigger factors, including sleep disturbance, work- or family-related issues, medication, and illicit drug use. There were no significant differences in any of the personality traits when comparing the 74 patients that reported triggers with the 90 patients that did not. At 7-year follow-up, there was no difference between the groups in number of affective episodes (depressive, hypomanic, manic, or mixed), involuntary commitments, suicide attempts, or self-harm incidents since baseline.
Around 40% of the patients reported external triggers for manic and hypomanic episodes. However, this was neither associated with personality traits nor number of affective episodes at 7-year follow-up.
研究触发躁狂和轻躁狂复发的外部因素，以及这些因素与人格和临床结局之间的关系，临床结局以 7 年内的情感发作次数来衡量。
这是一项前瞻性队列研究，共纳入 204 名精心描述的瑞典双相情感障碍患者。在 170 名患者中，基线时使用瑞典大学人格量表评估人格，大约 7 年后随访 90 名患者，以评估临床结局。
我们发现，44%的患者报告了触发因素，包括睡眠障碍、工作或家庭问题、药物治疗和非法药物使用。比较报告触发因素的 74 名患者和未报告触发因素的 90 名患者，他们在任何人格特征方面均无显著差异。在 7 年随访时，两组在情感发作次数（抑郁、轻躁狂、躁狂或混合发作）、非自愿住院、自杀未遂或自伤事件方面均无差异。
约 40%的患者报告了躁狂和轻躁狂发作的外部触发因素。然而，这与人格特征或 7 年随访时的情感发作次数无关。
