Department of Hematology, Yokohama Municipal Citizen's Hospital, Yokohama, Japan.
Division of Hematology, Keio University School of Medicine, Tokyo, Japan.
Leuk Lymphoma. 2020 Aug;61(8):1894-1900. doi: 10.1080/10428194.2020.1749608. Epub 2020 Apr 19.
The Controlling Nutritional Status (CONUT) score predicts the prognosis in several tumors. However, its prognostic significance in multiple myeloma (MM) remains unclear. The present study investigated the correlation between the CONUT score and the survival outcomes of MM patients. A total of 178 patients newly diagnosed with MM were retrospectively enrolled. Patients with a high CONUT score (≥5) had a significantly shorter median overall survival (OS) than those with a low CONUT score (≤4) (33 vs. 57 months, < .001). In a multivariate analysis among patients with International Staging System (ISS) score of ≤2, a high CONUT score was an independent prognostic covariate for the OS after adjusting for other significant factors (hazard ratio 2.364; 95% confidence interval 1.324-4.220, = .004). Our results suggest that the CONUT score is a predictor of a poor outcome in patients with MM, particularly in low-ISS-score cases.
营养状况控制评分（CONUT）可预测多种肿瘤的预后。然而，其在多发性骨髓瘤（MM）中的预后意义尚不清楚。本研究旨在探讨 CONUT 评分与 MM 患者生存结局之间的相关性。共回顾性纳入 178 例新诊断为 MM 的患者。高 CONUT 评分（≥5）患者的中位总生存期（OS）明显短于低 CONUT 评分（≤4）患者（33 个月 vs. 57 个月， < .001）。在 ISS 评分≤2 的患者中进行多变量分析，高 CONUT 评分是调整其他显著因素后 OS 的独立预后因素（风险比 2.364；95%置信区间 1.324-4.220， = .004）。我们的研究结果表明，CONUT 评分是 MM 患者预后不良的预测因子，尤其是在低 ISS 评分的情况下。
