Department of Internal Medicine CHU F Bourguiba Monastir, Geriatric unit, University Hospital F. Bourguiba, Monastir, Tunisia.
Biochemistry Laboratory, LR12ES05 LR-NAFS 'Nutrition - Functional Food & Vascular Health'Faculty of Medicine, University of Monastir, Monastir, Tunisia.
BMC Geriatr. 2020 Apr 19;20(1):144. doi: 10.1186/s12877-020-01545-4.
Frailty is a multidimensional syndrome that leads to an increase of an age-related disorder of several physiological systems, and cognitive abilities decline. The aim of this study was to evaluate the prevalence of frailty among older persons in Belgium and we examined the factors associated with frailty with a principal focus en cognitive, dietary status, and inflammatory parameters.
A total of 124 participants (90 women, 34 men; age: mean ± SD: 85.9 ± 5.5 years) were studied, recruited from the Geriatrics department, Belgium. Nutritional, cognitive status and physical activity were assessed using Mini Mental State Examination score (MMSE), Mini Nutritional Assessment score (MNA), and Katz score, respectively. Frailty syndrome was evaluated using the modified Short Emergency Geriatric Assessment (SEGA) score. Medication and medical history were recorded. Analyzed biochemical parameters included C-reactive protein (CRP), complete blood count, blood creatinine, vitamin D level, and serum protein electrophoresis. According to SEGA score, participants were divided into non-frail (n = 19), frail (n = 25) and severely frail patients (n = 80).
The SEGA score was inversely correlated with MMSE, MNA and Katz score. SEGA. score was negatively correlated to albumin levels (r = - 0.30; p < 0.001) and positively correlated to CRP, polypharmacy and age (r = 0.28, r = 0.37, r = 0.33 and p < 0.01 respectively). Logistic regression showed a strong association between frailty, Katz score, dementia, polypharmacy and living in nursing home.
Our results provide useful information for understanding mechanisms of frailty. This will help to develop preventive strategies for the elderly at the pre-frailty stage.
衰弱是一种多维度的综合征，导致与年龄相关的多个生理系统紊乱和认知能力下降。本研究旨在评估比利时老年人衰弱的患病率，并研究与衰弱相关的因素，主要关注认知、饮食状况和炎症参数。
共纳入 124 名参与者（90 名女性，34 名男性；年龄：平均±标准差：85.9±5.5 岁），他们来自比利时老年病科。使用简易精神状态检查评分（MMSE）、微型营养评估评分（MNA）和 Katz 评分分别评估营养状况、认知状态和身体活动。使用改良的短期急诊老年评估（SEGA）评分评估衰弱综合征。记录药物和病史。分析的生化参数包括 C 反应蛋白（CRP）、全血细胞计数、血肌酐、维生素 D 水平和血清蛋白电泳。根据 SEGA 评分，参与者分为非衰弱组（n=19）、衰弱组（n=25）和严重衰弱组（n=80）。
SEGA 评分与 MMSE、MNA 和 Katz 评分呈负相关。SEGA 评分与白蛋白水平呈负相关（r=-0.30；p<0.001），与 CRP、多种药物治疗和年龄呈正相关（r=0.28、r=0.37、r=0.33，p<0.01）。Logistic 回归显示，衰弱与 Katz 评分、痴呆、多种药物治疗和居住在养老院之间存在强关联。
我们的研究结果为理解衰弱机制提供了有用的信息。这将有助于在衰弱前期为老年人制定预防策略。
