Velissaris Dimitrios, Pantzaris Nikolaos, Koniari Ioanna, Koutsogiannis Nikolaos, Karamouzos Vasilios, Kotroni Ioanna, Skroumpelou Anastasia, Ellul John
Internal Medicine Department, University Hospital of Patras, Greece.
University Hospital of Patras, Greece.
J Clin Med Res. 2017 Jun;9(6):461-465. doi: 10.14740/jocmr2959w. Epub 2017 Apr 26.
Chronic inflammation is a well-established background process in many age-related diseases. Many recent studies investigate the use of various inflammatory biomarkers such as C-reactive protein (CRP), interleukin-6, and interleukin-1 as predictors of physical and cognitive performance among elders. The phenotype of frailty has also been associated with underlying inflammatory mechanisms. The aim of this article was to review the literature referring to the correlation of CRP serum levels and frailty in older individuals. We tried to identify all relevant publications regarding the relation of CRP as an index of frailty in the elderly and its potential use. Although many studies in the recent medical literature positively associate serum CRP levels and frailty in older individuals, some do not, and some raise some interesting questions and set the basis for future studies. The association of CRP and frailty in elder patients should be considered when clinicians interpret inflammatory biomarkers in various clinical settings in such patients. Well-designed, prospective clinical trials are warranted to better assess the role and pathophysiology of frailty in the elderly and its mechanisms as also the exact role of CRP as an inflammatory marker and as a prognostic index in this syndrome.
慢性炎症是许多与年龄相关疾病中公认的背景过程。最近许多研究调查了使用各种炎症生物标志物，如C反应蛋白（CRP）、白细胞介素-6和白细胞介素-1作为老年人身体和认知表现的预测指标。衰弱的表型也与潜在的炎症机制有关。本文的目的是综述关于老年人血清CRP水平与衰弱相关性的文献。我们试图找出所有关于CRP作为老年人衰弱指标及其潜在用途关系的相关出版物。尽管最近医学文献中的许多研究表明老年人血清CRP水平与衰弱呈正相关，但也有一些研究并非如此，还有一些研究提出了一些有趣的问题，并为未来的研究奠定了基础。当临床医生在这类患者的各种临床环境中解释炎症生物标志物时，应考虑老年患者中CRP与衰弱的关联。有必要进行精心设计的前瞻性临床试验，以更好地评估衰弱在老年人中的作用和病理生理学及其机制，以及CRP作为炎症标志物和该综合征预后指标的确切作用。
