Georgetown University, Washington, DC, USA.
Hum Immunol. 2021 Jul;82(7):457-465. doi: 10.1016/j.humimm.2020.03.005. Epub 2020 May 8.
The development of a standardized HLA nomenclature has been critical in our understanding of the HLA system and in facilitating the clinical applications of HLA. The Nomenclature Committee for Factors of the HLA System, established in 1968, has overseen the development and usage of nomenclature based on serologic specificities, cellular responses, and DNA sequences. Their decisions have been guided by community consensus reached through 17 international workshops beginning in 1964 and continuing today. Two websites provide a curated database of the sequences of over 26,000 HLA alleles and a reference site for the current nomenclature. This review covers the major steps in the development of the HLA nomenclature as well as the efforts of other groups to extend its usefulness for research and clinical applications.
HLA 命名法的标准化发展对于我们理解 HLA 系统和促进 HLA 的临床应用至关重要。1968 年成立的 HLA 系统因子命名委员会负责监督基于血清特异性、细胞反应和 DNA 序列的命名法的开发和使用。他们的决策是通过从 1964 年开始并持续到今天的 17 次国际研讨会达成的社区共识来指导的。两个网站提供了一个经过整理的超过 26000 个 HLA 等位基因序列数据库和当前命名法的参考站点。这篇综述涵盖了 HLA 命名法的主要发展步骤以及其他团体为扩展其在研究和临床应用中的用途所做的努力。
