Department of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Jilin Province, China.
Department of General Surgery, Taihe County People's Hospital, Anhui Province, China.
Pathol Res Pract. 2020 Jun;216(6):152949. doi: 10.1016/j.prp.2020.152949. Epub 2020 Apr 13.
The present meta-analysis has evaluated the association between lncRNA ATB, prognosis and clinicopathological parameters in patients with digestive cancers.
Eligible studies were gathered from Web of Science, PubMed, Embase, Cochrane Library, WanFang databases and China National Knowledge Infrastructure (up to October 15, 2019). Hazard ratios (HRs) and 95 % confidence intervals (CIs) were calculated to estimate the prognosis and clinicopathological parameters of lncRNA ATB in patients with digestive cancers.
We divided this study into two groups, pancreatic cancer (PC, downregulation) and non-pancreatic cancer (non-PC, upregulation). In the non-PC group, high expression levels of lncRNA ATB were significantly related to poor OS (pooled HR = 2.19, 95 % CI 1.68-2.85, P＜0.00001). In contrast, increased levels of lncRNA ATB in pancreatic cancer tissue were favorable factors in OS (HR = 0.47, 95 % CI 0.32-0.69, P = 0.0001). The pooled data suggested that high expression levels of lncRNA ATB predicted a poor DFS in CRC and a poor RFS in HCC. Increased expression of lncRNA ATB was correlated with negative lymph node metastasis and TNM stage in the non-PC group. In contrast, lncRNA ATB were favorable factors for LNM and TNM stages in pancreatic cancer.
LncRNA ATBs, whether cancer promoters or suppressors, were potential biomarkers and therapeutic targets for digestive system cancers.
本荟萃分析评估了 lncRNA ATB 与消化系统癌症患者的预后和临床病理参数之间的关系。
从 Web of Science、PubMed、Embase、Cochrane 图书馆、万方数据库和中国国家知识基础设施（截至 2019 年 10 月 15 日）中收集符合条件的研究。计算风险比（HRs）和 95%置信区间（CIs），以评估 lncRNA ATB 对消化系统癌症患者的预后和临床病理参数的影响。
我们将这项研究分为两组，胰腺癌（PC，下调）和非胰腺癌（非-PC，上调）。在非-PC 组中，lncRNA ATB 的高表达水平与较差的 OS 显著相关（合并 HR = 2.19，95%CI 1.68-2.85，P＜0.00001）。相比之下，胰腺癌组织中 lncRNA ATB 水平的升高是 OS 的有利因素（HR = 0.47，95%CI 0.32-0.69，P = 0.0001）。汇总数据表明，lncRNA ATB 的高表达预示着 CRC 的DFS 较差和 HCC 的 RFS 较差。在非-PC 组中，lncRNA ATB 的高表达与阴性淋巴结转移和 TNM 分期呈负相关。相反，lncRNA ATB 是胰腺癌中 LNM 和 TNM 分期的有利因素。
lncRNA ATB 无论是癌症促进因子还是抑制因子，都是消化系统癌症的潜在生物标志物和治疗靶点。
