[胃癌中Claudin-3的表达]

[Claudin-3 expression in gastric cancer].

作者信息

Danilova N V, Anikina K A, Oleynikova N A, Vychuzhanin D V, Malkov P G

机构信息

Medical Research and Educational Center, M.V. Lomonosov Moscow State University, Moscow, Russia.

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.

出版信息

Arkh Patol. 2020;82(2):5-11. doi: 10.17116/patol2020820215.

DOI:10.17116/patol2020820215

PMID:32307433

Abstract

UNLABELLED

Claudins are a family of transmembrane proteins which are essential for the formation and maintenance of epithelial tight junctions. Altered expression of claudins may lead to structural and functional damage of tight junctions, which plays an important role in tumorigenesis and cancer progression. The expression of claudin-3 in gastric cancer is not yet well understood.

AIM

To evaluate the expression of claudin-3 in gasric cancer and in adjacent normal mucosa and its association with clinical and pathological parameters.

SUBJECT AND METHODS

Tissue specimens from a total of 69 patients with gastric cancer were obtained. Immunohistochemical reactions were performed using mouse polyclonal antibodies to claudin-3.

RESULTS

The expression of claudin-3 in gastric cancer was significantly higher than in adjacent normal mucosa (p<0,05). The absence of claudin-3 was significantly associated with poor differentiation (p<0,05). An abnormal nuclear expression of claudin-3 was observed in 69.6% cases. A significant association was found between nuclear expression and the absence of membranous claudin-3 expression (p<0,05).

摘要