Wang Haiming, Yang Xingwang
Department of General Surgery, People's Hospital of Linzi District, Affiliated to Binzhou Medical College Zibo, Shandong Province, China.
Int J Clin Exp Pathol. 2015 Jan 1;8(1):881-7. eCollection 2015.
Recently, there is growing evidence that tight junction proteins are often abnormally regulated in human tumors. The function of tight junction proteins in the maintenance of normal epithelial physiology has been well discussed, but their role in the tumorigenesis of gastric cancer is less well defined. To explore the expression distinction of the tight junction proteins claudin-1, -3, and -4 expression in the gastric cancer, the expression of claudin-1, -3, and -4 in 92 gastric cancer tissues and the non-neoplastic tissues adjacent to the tumors were examined by immunohistochemistry. Compared with adjacent non-neoplastic tissues, the expression of claudin-1 was down regulated. However, the expression of claudin-3 and claudin-4 were up-regulated in gastric cancer tissue. In addition, the expression of claudin-3 is correlated with claudin-4 expression in gastric cancer. Our present study reveals that claudin-1, -3, and -4 protein expression altered between human gastric cancers and adjacent non-neoplastic tissues.
最近，越来越多的证据表明紧密连接蛋白在人类肿瘤中常常受到异常调控。紧密连接蛋白在维持正常上皮生理功能中的作用已得到充分讨论，但其在胃癌发生中的作用尚不清楚。为了探究紧密连接蛋白claudin-1、-3和-4在胃癌中的表达差异，采用免疫组织化学方法检测了92例胃癌组织及其癌旁非肿瘤组织中claudin-1、-3和-4的表达。与癌旁非肿瘤组织相比，claudin-1的表达下调。然而，claudin-3和claudin-4在胃癌组织中的表达上调。此外，claudin-3的表达与胃癌中claudin-4的表达相关。我们目前的研究表明，claudin-1、-3和-4蛋白表达在人类胃癌和癌旁非肿瘤组织之间存在差异。
