Department of General and Bariatric Surgery and Emergency Medicine, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.
Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, Zabrze, Poland.
Obes Surg. 2020 Sep;30(9):3417-3425. doi: 10.1007/s11695-020-04580-7.
The present study aims to clarify the effects of weight loss on biomarkers associated with angiogenesis in patients who underwent laparoscopic sleeve gastrectomy (SG) or adjustable gastric banding (LAGB) in the 12-month follow-up study.
We studied 24 obese patients who underwent laparoscopic weight loss surgery, 13 of whom underwent SG and 11 of whom underwent LAGB. We evaluated the circulating level of angiogenesis biomarkers preoperatively and 12 months after surgery.
Before surgery, the following angiogenic circulating factors were significantly higher than those of healthy subjects: angiopoietin 2 (ANG-2) (p < .05), granulocyte colony-stimulating factor (G-CSF) (p < .05), hepatocyte growth factor (HGF) (p < .01), platelet endothelial cell adhesion molecule (PECAM-1) (p < .01), and vascular endothelial growth factor (VEGF) (p < .05). The following angiogenesis biomarkers decreased significantly after weight loss compared with their baseline values: ANG-2 (p < .05), follistatin (p < .05), HGF (p < .01), PECAM-1 (p < .01), and VEGF (p < .05). There were no significant differences in the circulating levels of angiogenesis biomarkers between individuals who underwent SG and those who underwent LAGB; however, HGF, PECAM-1, and VEGF tended to be lower after SG. %BMI correlated negatively with HGF, PECAM-1, and VEGF. A similar significant negative correlation was found for %WL and %EWL. WHR correlated with PDGF-B and VEGF.
We concluded that weight loss surgery induces the changes of circulating levels of angiogenesis biomarkers in obese patients. The changes in angiogenesis status in obese patients who lost weight after bariatric surgery depended on the amount of weight loss.
本研究旨在阐明在腹腔镜袖状胃切除术（SG）或可调胃束带术（LAGB）后的 12 个月随访研究中，减肥对与血管生成相关的生物标志物的影响。
我们研究了 24 例接受腹腔镜减肥手术的肥胖患者，其中 13 例接受 SG，11 例接受 LAGB。我们评估了手术前和手术后 12 个月的循环血管生成生物标志物水平。
手术前，以下血管生成循环因子明显高于健康受试者：血管生成素 2（ANG-2）（p<0.05）、粒细胞集落刺激因子（G-CSF）（p<0.05）、肝细胞生长因子（HGF）（p<0.01）、血小板内皮细胞黏附分子（PECAM-1）（p<0.01）和血管内皮生长因子（VEGF）（p<0.05）。与基线值相比，减肥后以下血管生成生物标志物显著降低：ANG-2（p<0.05）、卵泡抑素（p<0.05）、HGF（p<0.01）、PECAM-1（p<0.01）和 VEGF（p<0.05）。SG 和 LAGB 组之间的血管生成生物标志物循环水平没有差异；然而，SG 后 HGF、PECAM-1 和 VEGF 趋于降低。%BMI 与 HGF、PECAM-1 和 VEGF 呈负相关。%WL 和%EWL 也发现了类似的显著负相关。WHR 与 PDGF-B 和 VEGF 相关。
我们得出结论，减肥手术会引起肥胖患者循环水平血管生成生物标志物的变化。减肥手术后肥胖患者血管生成状态的变化取决于减肥的量。
