Microbiota Interaction with Human and Animal Team (MIHA), Micalis Institute, AgroParisTech, Université Paris-Saclay, INRAE, Jouy-en-Josas, France.
FASEB J. 2020 Jun;34(6):7270-7282. doi: 10.1096/fj.202000031RR. Epub 2020 Apr 19.
Serine proteases have been long recognized to coordinate many physiological processes and play key roles in regulating the inflammatory response. Accordingly, their dysregulation has been regularly associated with several inflammatory disorders and suggested as a central mechanism in the pathophysiology of digestive inflammation. So far, studies addressing the proteolytic homeostasis in the gut have mainly focused on host serine proteases as candidates of interest, while largely ignoring the potential contribution of their bacterial counterparts. The human gut microbiota comprises a complex ecosystem that contributes to host health and disease. Yet, our understanding of microbially produced serine proteases and investigation of whether they are causally linked to IBD is still in its infancy. In this review, we highlight recent advances in the emerging roles of host and bacterial serine proteases in digestive inflammation. We also discuss the application of available tools in the gut to monitor disease-related serine proteases. An exhaustive representation and understanding of such functional potential would help in closing existing gaps in mechanistic knowledge.
丝氨酸蛋白酶长期以来被认为能够协调许多生理过程，并在调节炎症反应中发挥关键作用。因此，它们的失调经常与几种炎症性疾病有关，并被认为是消化炎症病理生理学的中心机制。到目前为止，研究肠道内的蛋白水解动态平衡主要集中在宿主丝氨酸蛋白酶作为候选物上，而在很大程度上忽略了其细菌对应物的潜在贡献。人类肠道微生物群是一个复杂的生态系统，有助于宿主的健康和疾病。然而，我们对微生物产生的丝氨酸蛋白酶的理解以及对它们是否与 IBD 有因果关系的研究仍处于起步阶段。在这篇综述中，我们强调了宿主和细菌丝氨酸蛋白酶在消化炎症中新兴作用的最新进展。我们还讨论了在肠道中应用现有工具来监测与疾病相关的丝氨酸蛋白酶。对这种功能潜力的详尽描述和理解将有助于弥合机制知识方面的现有差距。
