Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Farmacognosia, IQUIMEFA (UBA-CONICET), Buenos Aires, Argentina.
Drug Test Anal. 2020 Jul;12(7):861-886. doi: 10.1002/dta.2806. Epub 2020 May 29.
At present, there is a growing trend toward the intentional adulteration of dietary supplements (DS) with synthetic pharmaceuticals, which represents an alarming emerging risk to consumers and a serious problem for regulatory agencies. An amazing array of synthetic drugs and their analogues have been reported as adulterants in DS. Mainly, the presence of analogues represents a serious health risk as their efficacy and toxic effects have not been clinically assessed yet and may result in unpredictable adverse effects. The purpose of this review is to provide an overview, over the period 2009-2019, of the most frequently reported adulterants in DS for the treatment of erectile dysfunction, obesity/overweight, diabetes mellitus, and hypertension and the analytical methods used for their detection.
目前，在膳食补充剂（DS）中故意掺入合成药物的趋势日益明显，这对消费者来说是一个令人震惊的新风险，也是监管机构面临的一个严重问题。有大量的合成药物及其类似物被报道为 DS 的掺杂物。主要是，类似物的存在代表着严重的健康风险，因为它们的疗效和毒性作用尚未经过临床评估，可能导致不可预测的不良反应。本综述的目的是概述 2009 年至 2019 年期间，在治疗勃起功能障碍、肥胖/超重、糖尿病和高血压的 DS 中最常报告的掺杂物，以及用于检测它们的分析方法。
