寨卡病毒（ZIKV）甲基转移酶（MTase）结构域分析
Analysis of methyltransferase (MTase) domain from Zika virus (ZIKV).
作者信息
Afaq Sarah, Atiya Akhtar, Malik Arshi, Alwabli Afaf S, Alzahrani Dhafer A, Al-Solami Habeeb M, Alzahrani Othman, Alam Qamre, Kamal Mohammad Azhar, Abulfaraj Aala A, Alhebshi Alawiah M, Tarique Mohammed
机构信息
Department of Clinical Biochemistry, College of Medicine, King Khalid University, Abha, Kingdom of Saudi Arabia.
Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Kingdom of Saudi Arabia.
出版信息
Bioinformation. 2020 Mar 31;16(3):229-235. doi: 10.6026/97320630016229. eCollection 2020.
A comprehensive analysis of methyltransferase (MTase) from Zika virus (ZIKV) is of interest in the development of drugs and biomarkers in the combat and care of ZIKA fever with impulsive joint pain and conjunctivitis. MTase sequence is homologous in several viral species. We analyzed the MTase domain from ZIKV using Bioinformatics tools such as SMART, PROSITE, PFAM, PANTHER, and InterProScan to glean insights on the sequence to structure to function data. We document inclusive information on MTase from ZIKV for application in the design of drugs and biomarkers to fight against the disease.
对寨卡病毒（ZIKV）甲基转移酶（MTase）进行全面分析，对于开发治疗伴有突发性关节疼痛和结膜炎的寨卡热的药物及生物标志物具有重要意义。MTase序列在几种病毒物种中具有同源性。我们使用SMART、PROSITE、PFAM、PANTHER和InterProScan等生物信息学工具分析了ZIKV的MTase结构域，以深入了解其从序列到结构再到功能的数据。我们记录了有关ZIKV中MTase的全面信息，以便将其应用于对抗该疾病的药物和生物标志物设计中。
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