Curl J L
Southern Illinois University School of Medicine, Carbondale 62901.
Lab Anim. 1988 Oct;22(4):309-12. doi: 10.1258/002367788780746269.
The combination of ketamine-xylazine was assessed as a surgical anaesthetic in Djungarian hamsters acclimatized to both long (16 h light: 8 h dark) and short (8 h light: 16 h dark) photoperiods. It was concluded that 50 mg/kg of ketamine with 10 mg/kg of xylazine or 100 mg/kg of ketamine with 5-10 mg/kg of xylazine when given together by intraperitoneal injection was a satisfactory general anaesthetic. Two hundred mg/kg of ketamine with 10 mg/kg xylazine caused death in 13 of 24 animals. There were no clinically significant effects on depth of anaesthesia due to photoperiod.
在适应长光照周期（16小时光照：8小时黑暗）和短光照周期（8小时光照：16小时黑暗）的黑线毛足鼠中，评估了氯胺酮-赛拉嗪组合作为手术麻醉剂的效果。得出的结论是，当通过腹腔注射联合给予时，50毫克/千克氯胺酮与10毫克/千克赛拉嗪或100毫克/千克氯胺酮与5 - 10毫克/千克赛拉嗪是一种令人满意的全身麻醉剂。200毫克/千克氯胺酮与10毫克/千克赛拉嗪导致24只动物中有13只死亡。光照周期对麻醉深度没有临床显著影响。
