Payton A J, Forsythe D B, Dixon D, Myers P H, Clark J A, Snipe J R
Comparative Medicine Branch, National Institute of Environmental Health Science, National Institutes of Health, Research Triangle Park, NC 27709.
Cornell Vet. 1993 Apr;83(2):153-61.
Few parenteral anesthetics are safe and effective in the Syrian hamster. This study evaluated the anesthetic efficacy and potential for tissue damage of ketamine-xylazine (KX). Two dosage levels were administered intraperitoneally. Ketamine at 50 mg/kg combined with 10 mg/kg xylazine did not produce a consistent, reliable level of immobilization or anesthesia. Ketamine at 150 mg/kg combined with 10 mg/kg xylazine administered IP produced an adequate level of anesthesia without tissue damage for most procedures, but supplementation with lidocaine was necessary for peritoneal incision. Careful positioning of male hamsters for IP injection is imperative to prevent inadvertent injection into the testes with subsequent tissue damage.
很少有胃肠外麻醉剂在叙利亚仓鼠身上是安全有效的。本研究评估了氯胺酮-赛拉嗪（KX）的麻醉效果及组织损伤可能性。通过腹腔注射给予两种剂量水平。50mg/kg氯胺酮与10mg/kg赛拉嗪联合使用时，无法产生持续、可靠的制动或麻醉水平。腹腔注射150mg/kg氯胺酮与10mg/kg赛拉嗪，对大多数手术可产生足够的麻醉水平且无组织损伤，但腹膜切开术需补充利多卡因。对雄性仓鼠进行腹腔注射时，必须小心定位，以防止意外注入睾丸并导致后续组织损伤。
