Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran.
Department of Physiology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.
Oxid Med Cell Longev. 2020 Mar 10;2020:6969402. doi: 10.1155/2020/6969402. eCollection 2020.
Mitophagy is a protected cellular process that is essential for autophagic removal of damaged mitochondria and for preservation of a healthy mitochondrial population. In the last years, a particular interest has been devoted in studying the effects of natural compounds on mitophagy. Different natural compounds may modulate mitochondrial oxidative phosphorylation, the production of mitochondrial reactive oxygen species, the expression of mitophagy- and autophagy-related genes, and the activities of transcription factors which regulate the expression of mitochondrial proteins, thereby controlling mitochondrial damage and mitophagy. Remarkably, since mitochondrial function has a crucial role in the pathogenesis of various diseases (e.g., cancer, atherosclerosis, Duchenne muscular dystrophy, diabetes complications, Alzheimer's disease, and hepatic steatosis), these effects might have important therapeutic implications. In this review, preclinical studies investigating the role of different natural compounds in the modulation of mitophagy will be discussed.
自噬是一种受保护的细胞过程，对于清除受损线粒体和维持健康的线粒体种群至关重要。在过去的几年中，人们对研究天然化合物对自噬的影响产生了特别的兴趣。不同的天然化合物可能调节线粒体氧化磷酸化、线粒体活性氧的产生、自噬和自噬相关基因的表达，以及调节线粒体蛋白表达的转录因子的活性，从而控制线粒体损伤和自噬。值得注意的是，由于线粒体功能在各种疾病（如癌症、动脉粥样硬化、杜氏肌营养不良症、糖尿病并发症、阿尔茨海默病和肝脂肪变性）的发病机制中起着至关重要的作用，这些影响可能具有重要的治疗意义。在这篇综述中，将讨论不同天然化合物在调节自噬中的作用的临床前研究。
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