Copur Busra, Yilmaz Nisbet, Topcuoglu Canan, Kiziltunc Emrullah, Cetin Mustafa, Turhan Turan, Demir Burak Furkan, Altiparmak Emin, Ates Ihsan
Ankara Numune Training and Research Hospital, Internal Medicine Department, Ankara, Turkey.
Ankara Numune Training and Research Hospital, Department of Biochemistry, Ankara, Turkey.
Gastroenterol Hepatol Bed Bench. 2020 Spring;13(2):133-140.
This study aimed to determine oxidant status and left ventricular mass index (LVMI) and their relationship with mild hyperbilirubinemia in patients with Gilbert syndrome (GS).
Gilbert syndrome (GS) presents with mild indirect hyperbilirubinemia, normal liver function tests, and normal hepatic histology.
A total of 84 patients, including 41 (48.8%) patients with GS and 43 (51.2%) patients without GS, were included in the study. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were examined for oxidant status.
TAS was found to be higher in the GS patients compared to the non-GS patients (1.7±0.1 vs. 1.5±0.2; p=0.002); there was no significant difference between the groups in terms of mean TOS and mean OSI (p>0.05). No significant difference was observed either between the GS and non-GS patients in terms of mean left ventricular volume and mean LVMI (p>0.05). However, subgroup analysis based on sex revealed that GS patients had a lower LVMI for both sexes. In GS patients, TAS level had a positive correlation with albumin (r=0.319; p=0.042), triglyceride (r=0.392; p=0.011), total bilirubin (r=0.420; p=0.006), direct bilirubin (r=0.361; p=0.020), and indirect bilirubin (r=0.338; p=0.0311) levels; no correlation was found between TAS level and other laboratory findings (p>0.05). The regression model indicated that risk factors of direct bilirubin (β±SE=0.13±0.03; p<0.001), uric acid (β±SE=0.04±0.01; p=0.001), and albumin (β±SE=0.17±0.04; p<0.001) were independent predictors of TAS level.
This study revealed a relationship between mild hyperbilirubinemia and antioxidant balance in GS. Although statistical significance was not reached, LVMI was found to be lower in the GS group compared to the non-GS group for both sexes.
本研究旨在确定吉尔伯特综合征（GS）患者的氧化状态和左心室质量指数（LVMI）及其与轻度高胆红素血症的关系。
吉尔伯特综合征（GS）表现为轻度间接高胆红素血症、肝功能检查正常和肝脏组织学正常。
本研究共纳入84例患者，其中41例（48.8%）为GS患者，43例（51.2%）为非GS患者。检测总抗氧化状态（TAS）、总氧化状态（TOS）和氧化应激指数（OSI）以评估氧化状态。
发现GS患者的TAS高于非GS患者（1.7±0.1对1.5±0.2；p=0.002）；两组之间的平均TOS和平均OSI无显著差异（p>0.05）。GS患者和非GS患者之间的平均左心室容积和平均LVMI也无显著差异（p>0.05）。然而，按性别进行的亚组分析显示，GS患者无论男女LVMI均较低。在GS患者中，TAS水平与白蛋白（r=0.319；p=0.042）、甘油三酯（r=0.392；p=0.011）、总胆红素（r=0.420；p=0.006）、直接胆红素（r=0.361；p=0.020）和间接胆红素（r=0.338；p=0.0311）水平呈正相关；未发现TAS水平与其他实验室检查结果之间存在相关性（p>0.05）。回归模型表明，直接胆红素（β±SE=0.13±0.03；p<0.001）、尿酸（β±SE=0.04±0.01；p=0.001）和白蛋白（β±SE=0.17±0.04；p<0.001）是TAS水平的独立预测因素。
本研究揭示了GS患者轻度高胆红素血症与抗氧化平衡之间的关系。尽管未达到统计学显著性，但发现GS组无论男女LVMI均低于非GS组。
