Xiao Yue-Yan, Wei Wen-Bin, Wang Ya-Xing, Lu Ai-Dong, Chen Shuo-Hua, Song Lu, Wu Shou-Ling
Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
Department of Ophthalmology, Kailuan General Hospital, Tangshan 063000, Hebei Province, China.
Int J Ophthalmol. 2020 Mar 18;13(3):431-437. doi: 10.18240/ijo.2020.03.10. eCollection 2020.
To analyze the systemic factors including stroke history related to the retinal artery occlusion (RAO).
Patients with an exact diagnosis of RAO in the medical database of the Kailuan Corporation were identified as the case group. Five patients without RAO were added for each case from the Kailuan Study and matched for sex and age (age±2) as the control group. The Kailuan Study is a general population-based cohort study in northern China, in which a total of 101 510 individuals (81 110 men) aged 18-98y were recruited to participate in the study. And the participants were bi-annually re-examined. The database of both groups was from Kailuan study of 2010 cohort. All the information, including the demographic characteristics, lifestyle behaviors, medical comorbidities, medical history, family medical history, drug usage, anthropometric measurements, blood pressure measurement, blood sample laboratory assessment, urine tests, and other physical examinations were all collected. A retrospective nested case-control method was used for this study. Conditional multivariate logistic regression was used to analyze the risk factors with SPSS 13.0 software and SAS 9.3 software.
A total of 45 patients were included as the case group, and the control group included 225 patients. In the case group, 28 patients (62.2%) had a central retinal artery occlusion (CRAO), and 17 patients (37.8%) had a branch retinal artery occlusion (BRAO). A total of 18 patients (40.0%) had a stroke before the RAO (mean 4.04±3.88y before the RAO), and 31 patients (81.6%) had infarctions or malacia identified by the cranial computed tomography (CT) scans. The basal ganglia and centrum semiovale were the most frequently involved regions. Plaques in the common carotid artery were present in 32 patients (88.9%). Conditional multivariate logistic regression analysis showed that the RAO was found to be associated with the history of stroke (=0.0023, OR=28.794; 95%CI: 3.322-249.586).
A history of stroke can significantly increase the incidence of RAO. Exists of plaque in the carotid artery is mean more than its severe stenosis for RAO.
分析包括卒中病史在内的与视网膜动脉阻塞（RAO）相关的全身因素。
在开滦集团医疗数据库中确诊为RAO的患者被确定为病例组。从开滦研究中为每个病例额外选取5名无RAO的患者，并按照性别和年龄（年龄±2岁）进行匹配作为对照组。开滦研究是一项基于中国北方普通人群的队列研究，共招募了101510名年龄在18 - 98岁的个体（81110名男性）参与研究。参与者每半年接受一次复查。两组的数据库均来自2010年队列的开滦研究。收集了所有信息，包括人口统计学特征、生活方式行为、医疗合并症、病史、家族病史、药物使用情况、人体测量、血压测量、血样实验室评估、尿液检查及其他体格检查。本研究采用回顾性巢式病例对照方法。使用SPSS 13.0软件和SAS 9.3软件进行条件多因素逻辑回归分析危险因素。
共纳入45例患者作为病例组，对照组包括225例患者。病例组中，28例患者（62.2%）发生中央视网膜动脉阻塞（CRAO），17例患者（37.8%）发生分支视网膜动脉阻塞（BRAO）。共有18例患者（40.0%）在发生RAO之前有卒中史（RAO前平均4.04±3. ...
