大型横断面队列中视网膜血管阻塞与认知性痴呆的关系
Relationship between Retinal Vascular Occlusions and Cognitive Dementia in a Large Cross-Sectional Cohort.
作者信息
Chan Alison X, Bakhoum Christine Y, Bangen Katherine J, Bakhoum Mathieu F
机构信息
From the Viterbi Family Department of Ophthalmology (AXC, MFB), Shiley Eye Institute, University of California San Diego, La Jolla, California, USA; Division of Pediatric Nephrology (CYB), Rady Children's Hospital San Diego, University of California San Diego, San Diego, California, USA; Research Service (KJB), Veterans' Affairs San Diego Healthcare System, La Jolla, California, USA; Department of Psychiatry (KJB), University of California San Diego, La Jolla, California.
From the Viterbi Family Department of Ophthalmology (AXC, MFB), Shiley Eye Institute, University of California San Diego, La Jolla, California, USA; Division of Pediatric Nephrology (CYB), Rady Children's Hospital San Diego, University of California San Diego, San Diego, California, USA; Research Service (KJB), Veterans' Affairs San Diego Healthcare System, La Jolla, California, USA; Department of Psychiatry (KJB), University of California San Diego, La Jolla, California.
出版信息
Am J Ophthalmol. 2021 Jun;226:201-205. doi: 10.1016/j.ajo.2021.01.026. Epub 2021 Jan 30.
PURPOSE
To examine the association between cognitive dementia and retinal vascular occlusions.
DESIGN
A retrospective, cross-sectional study.
METHODS
Single-institution study population: we reviewed the electronic medical records of 37,208 individuals older than 65 years of age who were evaluated by an ophthalmologist or an optometrist and who also had a medical visit to our institution over a 6-year period. Individuals with and without retinal vascular occlusions were identified by International Classification of Diseases, version 10 (ICD-10) diagnostic codes.
MAIN OUTCOME
we analyzed the association between dementia and retinal vascular occlusions after adjusting for covariates which included age, sex, stroke, diabetes mellitus, and hypertension using multiple logistic regression analyses.
RESULTS
Compared to subjects without retinal vascular occlusions, those with retinal vascular occlusions had a higher prevalence of dementia (6.7% vs. 9.3%, respectively; P < .001). After adjusting for either age or stroke, there were no significant associations between retinal vascular occlusions and dementia.
CONCLUSIONS
Individuals with retinal vascular occlusions have a higher prevalence of dementia. However, this association is secondary to shared underlying risk factors in this population, such as older age and stroke.
目的
研究认知性痴呆与视网膜血管阻塞之间的关联。
设计
一项回顾性横断面研究。
方法
单机构研究人群：我们回顾了37208名65岁以上个体的电子病历，这些个体由眼科医生或验光师进行了评估，并且在6年期间也到我们机构进行过医疗就诊。通过国际疾病分类第10版（ICD - 10）诊断代码确定有无视网膜血管阻塞的个体。
主要结局
我们使用多因素逻辑回归分析，在调整了包括年龄、性别、中风、糖尿病和高血压等协变量后，分析痴呆与视网膜血管阻塞之间的关联。
结果
与没有视网膜血管阻塞的受试者相比，有视网膜血管阻塞的受试者痴呆患病率更高（分别为6.7%和9.3%；P < 0.001）。在调整年龄或中风因素后，视网膜血管阻塞与痴呆之间无显著关联。
结论
有视网膜血管阻塞的个体痴呆患病率较高。然而，这种关联是该人群中共同的潜在危险因素（如年龄较大和中风）所致。
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