Ma Jianxin, Cui Lian, Huo Wenjin, Wang Guanghui, Quan Xin, Zhang Jinping
Department of Health Care, 305 Hospital of Chinese PLA, Beijing 100017, P.R. China.
Department of Echocardiography, Fuwai Hospital, Peking Union Medical College, Beijing 100017, P.R., China.
Iran J Public Health. 2020 Jan;49(1):30-36.
The correlation between postoperative deep venous thrombosis (DVT) and inflammation in patients with permanent cardiac pacemaker implantation was analyzed.
A total of 130 cases undergoing permanent pacemaker implantation in the 305 Hospital of Chinese PLA and Fuwai Hospital from May 2014 to February 2017 were selected. Of the 130 cases, 60 patients complicated with DVT were selected as the observation group, and the remaining 70 cases without complications of DVT were selected as the control group. The relationship and influence of various factors were explored.
The number of patients smoking and the number of subjects with DVT history in the observation group were higher than those in the control group. In the observation group, plasminogen activator inhibitor (PAI)-1: Ag, PAI-1: Ac, thrombin-activated fibrinolysis inhibitor (TAFI): Ag, and TAFI: Ac levels were higher than those in control group (<0.05). The levels of inflammatory factors of the peripheral blood of the observation group were significantly higher than those of the control group (<0.05). In the correlation analysis of serum inflammatory factors and coagulation factors, CRP, IL-6, IL-10 were positively correlated with PAI-1: Ag level. Age, BMI, smoking history, number of implanted electrodes, DVT history, duration of immobilization and inflammatory factor levels had independent predictive value on postoperative complicated DVT.
The serum inflammatory factors are closely associated with postoperative DVT in patients implanted with permanent cardiac pacemaker, and the serum inflammatory factors are a good reference for the evaluation of DVT.
分析永久性心脏起搏器植入患者术后深静脉血栓形成（DVT）与炎症之间的相关性。
选取2014年5月至2017年2月在中国人民解放军第305医院和阜外医院接受永久性起搏器植入的130例患者。在这130例患者中，选取60例并发DVT的患者作为观察组，其余70例未发生DVT并发症的患者作为对照组。探讨各种因素之间的关系及影响。
观察组吸烟患者数量及有DVT病史的受试者数量高于对照组。观察组中，纤溶酶原激活物抑制剂（PAI）-1：Ag、PAI-1：Ac、凝血酶激活的纤溶抑制物（TAFI）：Ag及TAFI：Ac水平高于对照组（<0.05）。观察组外周血炎症因子水平显著高于对照组（<0.05）。在血清炎症因子与凝血因子的相关性分析中，CRP、IL-6、IL-10与PAI-1：Ag水平呈正相关。年龄、BMI、吸烟史、植入电极数量、DVT病史、制动时间及炎症因子水平对术后并发DVT具有独立预测价值。
血清炎症因子与永久性心脏起搏器植入患者术后DVT密切相关，血清炎症因子是评估DVT的良好参考指标。
