血清 PSP/REG I 与 2 型糖尿病患者肾功能的关系。
Association of Serum PSP/REG I with Renal Function in Type 2 Diabetes Mellitus.
机构信息
Department of Endocrinology, Zhongda Hospital, School of Medicine, Southeast University, No. 87 Dingjiaqiao, Nanjing, Jiangsu 210009, China.
Pancreatic Research Institute, Southeast University, China.
出版信息
J Diabetes Res. 2020 Mar 23;2020:9787839. doi: 10.1155/2020/9787839. eCollection 2020.
PURPOSE
Pancreatic stone protein/regenerating protein I (PSP/REG I) is a secretory protein mainly detected in the pancreas. Recent studies revealed increased serum PSP/REG I) is a secretory protein mainly detected in the pancreas. Recent studies revealed increased serum PSP/REG I) is a secretory protein mainly detected in the pancreas. Recent studies revealed increased serum PSP/REG I.
METHODS
This cross-sectional study was conducted at Zhongda Hospital, affiliated with Southeast University in China. Serum PSP/REG I) is a secretory protein mainly detected in the pancreas. Recent studies revealed increased serum PSP/REG I) is a secretory protein mainly detected in the pancreas. Recent studies revealed increased serum PSP/REG I.
RESULTS
Serum PSP/REG I) is a secretory protein mainly detected in the pancreas. Recent studies revealed increased serum PSP/REG I < 0.05). The level of PSP/REG I) is a secretory protein mainly detected in the pancreas. Recent studies revealed increased serum PSP/REG I) is a secretory protein mainly detected in the pancreas. Recent studies revealed increased serum PSP/REG I.
CONCLUSIONS
Serum PSP/REG I level is significantly upregulated in T2DM patients and reflects renal function in both T2DM and nondiabetic control groups. The relationship between PSP/REG I and eGFR suggested that PSP/REG I might be a potential indicator of renal dysfunction.) is a secretory protein mainly detected in the pancreas. Recent studies revealed increased serum PSP/REG I) is a secretory protein mainly detected in the pancreas. Recent studies revealed increased serum PSP/REG I) is a secretory protein mainly detected in the pancreas. Recent studies revealed increased serum PSP/REG I.
目的
胰腺分泌蛋白/再生蛋白 I（PSP/REG I）是一种主要在胰腺中检测到的分泌蛋白。最近的研究表明，血清 PSP/REG I 水平在 2 型糖尿病（T2DM）患者中显著上调，并反映了 T2DM 和非糖尿病对照组的肾功能。PSP/REG I 与 eGFR 的关系表明，PSP/REG I 可能是肾功能障碍的潜在指标。
方法
本横断面研究在中国东南大学附属中大医院进行。
结果
与非糖尿病对照组相比，T2DM 患者的血清 PSP/REG I 水平显著升高（P<0.05）。在 T2DM 和非糖尿病对照组中，PSP/REG I 水平与 eGFR 呈负相关（r=-0.324，P<0.001；r=-0.315，P<0.001）。
结论
血清 PSP/REG I 水平在 T2DM 患者中显著上调，并反映了 T2DM 和非糖尿病对照组的肾功能。PSP/REG I 与 eGFR 的关系表明，PSP/REG I 可能是肾功能障碍的潜在指标。
Zotero 插件