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Recent Studies on the Insulin-Secreting Porosome Complex Provide Potential Therapeutic Applications in the Treatment of Diabetes.

作者信息

Anderson Lloyd L

机构信息

Department of Animal Science, College of Agriculture and Life Sciences and Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011-3150 USA.

出版信息

Discoveries (Craiova). 2015 Dec 4;3(4):e51. doi: 10.15190/d.2015.43.

DOI:10.15190/d.2015.43
PMID:32309573
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6941544/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b5e/6941544/720630a7bd46/discoveries-03-051-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b5e/6941544/720630a7bd46/discoveries-03-051-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b5e/6941544/720630a7bd46/discoveries-03-051-g001.jpg

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本文引用的文献

1
Functional Reconstitution of the Insulin-Secreting Porosome Complex in Live Cells.活细胞中胰岛素分泌孔体复合物的功能重建
Endocrinology. 2016 Jan;157(1):54-60. doi: 10.1210/en.2015-1653. Epub 2015 Nov 2.
2
The neuronal porosome complex in health and disease.健康与疾病中的神经元孔体复合物
Exp Biol Med (Maywood). 2016 Jan;241(2):115-30. doi: 10.1177/1535370215598400. Epub 2015 Aug 11.
3
'Porosome' discovered nearly 20 years ago provides molecular insights into the kiss-and-run mechanism of cell secretion.近20年前发现的“孔体”为细胞分泌的亲吻-逃离机制提供了分子层面的见解。
J Cell Mol Med. 2015 Jul;19(7):1427-40. doi: 10.1111/jcmm.12598. Epub 2015 May 28.
4
Proteome of the insulin-secreting Min6 cell porosome complex: involvement of Hsp90 in its assembly and function.胰岛素分泌型Min6细胞孔体复合物的蛋白质组:热休克蛋白90在其组装和功能中的作用
J Proteomics. 2015 Jan 30;114:83-92. doi: 10.1016/j.jprot.2014.11.010. Epub 2014 Nov 20.
5
Proteome of the porosome complex in human airway epithelia: interaction with the cystic fibrosis transmembrane conductance regulator (CFTR).人气道上皮细胞中孔体复合物的蛋白质组:与囊性纤维化跨膜传导调节因子(CFTR)的相互作用
J Proteomics. 2014 Jan 16;96:82-91. doi: 10.1016/j.jprot.2013.10.041. Epub 2013 Nov 9.
6
Hypokinetic stress and neuronal porosome complex in the rat brain: the electron microscopic study.运动不足应激和大鼠脑神经元多孔体复合物:电子显微镜研究。
Micron. 2012 Sep;43(9):948-53. doi: 10.1016/j.micron.2012.03.016. Epub 2012 Apr 6.
7
Intrahepatic transplanted islets in humans secrete insulin in a coordinate pulsatile manner directly into the liver.人体内肝内移植的胰岛以协调的脉冲方式直接向肝脏分泌胰岛素。
Diabetes. 2006 Aug;55(8):2324-32. doi: 10.2337/db06-0069.
8
{beta}-Cell function following human islet transplantation for type 1 diabetes.1型糖尿病患者胰岛移植后的β细胞功能
Diabetes. 2005 Jan;54(1):100-6. doi: 10.2337/diabetes.54.1.100.
9
Reconstituted fusion pore.重构融合孔
Biophys J. 2003 Sep;85(3):2035-43. doi: 10.1016/S0006-3495(03)74631-1.
10
Functional aspects of mouse islets transplanted to the kidney.
Diabetologia. 1994 Sep;37 Suppl 2:S112-6. doi: 10.1007/BF00400834.