AMPK激活可以延缓衰老。
AMPK activation can delay aging.
作者信息
Stancu Andreea L
机构信息
Department of Pathology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA.
出版信息
Discoveries (Craiova). 2015 Dec 31;3(4):e53. doi: 10.15190/d.2015.45.
Abstract
AMPK controls the regulation of cellular homeostasis, metabolism, resistance to stress, cell survival and growth, cell death, autophagy, which are some of the most critical determinants of aging and lifespan. Specific AMPK activation was recently shown to delay aging and prolong lifespan in Drosophila melanogaster. Indirect AMPK activators, such as resveratrol, metformin and exercise, are currently in clinical trials for studying their impact on human aging-related characteristics, tissue homeostasis and metabolic dysfunctions. In this minireview, I am briefly discussing the recent advances on AMP involvement in aging and lifespan elongation.
摘要
AMPK控制细胞内稳态、新陈代谢、应激抗性、细胞存活与生长、细胞死亡、自噬等过程的调节，而这些都是衰老和寿命的一些最关键决定因素。最近研究表明，特异性激活AMPK可延缓黑腹果蝇的衰老并延长其寿命。间接AMPK激活剂，如白藜芦醇、二甲双胍和运动，目前正处于临床试验阶段，以研究它们对人类衰老相关特征、组织内稳态和代谢功能障碍的影响。在这篇小型综述中，我将简要讨论AMP在衰老和寿命延长方面的最新研究进展。
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