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Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations.同源二聚体细胞因子受体的激活机制及致癌突变的失调。
Science. 2020 Feb 7;367(6478):643-652. doi: 10.1126/science.aaw3242.
2
JAK2 activation by growth hormone and other cytokines.生长激素和其他细胞因子对JAK2的激活作用。
Biochem J. 2015 Feb 15;466(1):1-11. doi: 10.1042/BJ20141293.
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Mechanism of activation of protein kinase JAK2 by the growth hormone receptor.生长激素受体激活蛋白激酶 JAK2 的机制。
Science. 2014 May 16;344(6185):1249783. doi: 10.1126/science.1249783.
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Thrombopoietin receptor activation: transmembrane helix dimerization, rotation, and allosteric modulation.促血小板生成素受体激活：跨膜螺旋二聚体化、旋转和变构调节。
FASEB J. 2011 Jul;25(7):2234-44. doi: 10.1096/fj.10-178673. Epub 2011 Mar 14.
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Mechanistic diversity of cytokine receptor signaling across cell membranes.细胞因子受体信号转导跨细胞膜的机制多样性。
Sci STKE. 2004 Apr 28;2004(231):re7. doi: 10.1126/stke.2312004re7.
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Efficiency of signalling through cytokine receptors depends critically on receptor orientation.细胞因子受体信号传导的效率关键取决于受体的取向。
Nature. 1998 Oct 1;395(6701):511-6. doi: 10.1038/26773.
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Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule.
Science. 1991 Nov 8;254(5033):821-5. doi: 10.1126/science.1948064.

There and Back Again: A Cytokine Receptor's Tail.

作者信息

Kent David

机构信息

York Biomedical Research Institute, Department of Biology, University of York, York, YO10 5DD, United Kingdom.

出版信息

Hemasphere. 2020 Feb 20;4(2):e349. doi: 10.1097/HS9.0000000000000349. eCollection 2020 Apr.

DOI:10.1097/HS9.0000000000000349
PMID:32309786
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7162087/
Abstract
摘要