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机械刺激通过 TWIST/E2A/p21 轴诱导 BMSCs 的成骨分化。

Mechanical stimulation induced osteogenic differentiation of BMSCs through TWIST/E2A/p21 axis.

机构信息

Institute of Stomatology, Chinese PLA General Hospital, Beijing 100853, China.

Department of Stomatology, Qingdao Municipal Hospital Group, Qingdao University, Qingdao, Shandong 266011, China.

出版信息

Biosci Rep. 2020 May 29;40(5). doi: 10.1042/BSR20193876.

DOI:10.1042/BSR20193876
PMID:32309849
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7199451/
Abstract

The relationship between mechanical force and alveolar bone remodeling is an important issue in orthodontics because tooth movement is dependent on the response of bone tissue to the mechanical force induced by the appliances used. Mechanical cyclical stretch plays an essential role in the cell osteogenic differentiation involved in bone remodeling. However, the underlying mechanisms are unclear, particularly the molecular pathways regulated by mechanical stimulation. In the present study, we reported a dynamic change of p21 level in response to mechanical cyclical stretch, and shRNA-p21 in bone marrow mesenchymal stem cells (BMSCs) induced osteogenic differentiation. The mechanism was mediated through TWIST/E2A/p21 axis. These results supported the mechanical stimulation-induced osteogenic differentiation is negatively regulated by p21.

摘要

机械力与牙槽骨重塑之间的关系是正畸学中的一个重要问题，因为牙齿的移动依赖于骨骼组织对正畸治疗中应用的矫治器产生的机械力的反应。机械循环拉伸在涉及骨重塑的细胞成骨分化中起着至关重要的作用。然而，其潜在机制尚不清楚，特别是机械刺激调节的分子途径。在本研究中，我们报道了 p21 水平对机械循环拉伸的动态变化，并报告了 shRNA-p21 在骨髓间充质干细胞（BMSCs）中诱导成骨分化。该机制是通过 TWIST/E2A/p21 轴介导的。这些结果支持机械刺激诱导的成骨分化受到 p21 的负调控。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1710/7199451/b6e97f20536a/bsr-40-bsr20193876-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1710/7199451/6e6f497a1e9a/bsr-40-bsr20193876-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1710/7199451/e2ce7cc67993/bsr-40-bsr20193876-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1710/7199451/d67a1e9634c5/bsr-40-bsr20193876-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1710/7199451/892f1a9a6a89/bsr-40-bsr20193876-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1710/7199451/b6e97f20536a/bsr-40-bsr20193876-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1710/7199451/6e6f497a1e9a/bsr-40-bsr20193876-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1710/7199451/e2ce7cc67993/bsr-40-bsr20193876-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1710/7199451/d67a1e9634c5/bsr-40-bsr20193876-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1710/7199451/892f1a9a6a89/bsr-40-bsr20193876-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1710/7199451/b6e97f20536a/bsr-40-bsr20193876-g5.jpg

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