Department of Pharmacy Practice, Faculty of Pharmacy, Princess Norah Bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia.
Research Department of Practice and Policy, University College London School of Pharmacy, London, United Kingdom.
J Alzheimers Dis. 2020;75(2):607-615. doi: 10.3233/JAD-191115.
Few studies have shown that an increased risk of dementia is associated with diabetes mellitus.
To estimate the prevalence and incidence of dementia in people with diabetes in primary care in the UK.
We conducted a descriptive study using the UK The Health Improvement Network (THIN) database. People diagnosed with diabetes from 2000 to 2016 were included in the study. Prevalence and incidence rates of dementia were calculated annually, stratified by age and gender.
The prevalence of dementia was 0.424% [95% CI (0.420%-0.427%)] in 2000 and 2.508% [95% CI (2.501%-2.515%)] in 2016. The highest prevalence was in those aged 85+ from 2.9% [95% CI (2.890%-2.974%)] in 2000 to 11.3% [95% CI (11.285%-11.384%)] in 2016. The incidence of dementia increased 3.7 times, from 0.181 cases per 100 persons [95% CI (0.179-0.183)] in 2000 to 0.683 cases per 100 persons [95% CI (0.679-0.686)] in 2016, respectively. Women had a higher prevalence and incidence of dementia than men 3.138% [95% CI (3.127%-3.150%)] versus 2.014% [95% CI (2.006%-2.022%)] and 0.820 [95% CI (0.814-0.826)] versus 0.576 cases per 100 persons [95% CI (0.571-0.580)] in 2016, respectively.
There was a trend of increasing prevalence and incidence of dementia in people with diabetes over the period of 2000 to 2016. This study adds to the evidence on dementia prevalence and incidence, particularly in the diabetic population.
很少有研究表明痴呆的风险增加与糖尿病有关。
评估英国初级保健中糖尿病患者痴呆的患病率和发病率。
我们使用英国健康改善网络（THIN）数据库进行了一项描述性研究。从 2000 年至 2016 年被诊断患有糖尿病的患者被纳入研究。每年按年龄和性别分层计算痴呆的患病率和发病率。
2000 年痴呆的患病率为 0.424%[95%置信区间（0.420%-0.427%）]，2016 年为 2.508%[95%置信区间（2.501%-2.515%）]。患病率最高的是 85 岁以上人群，2000 年为 2.9%[95%置信区间（2.890%-2.974%）]，2016 年为 11.3%[95%置信区间（11.285%-11.384%）]。痴呆的发病率增加了 3.7 倍，从 2000 年的每 100 人 0.181 例[95%置信区间（0.179-0.183）]增加到 2016 年的每 100 人 0.683 例[95%置信区间（0.679-0.686）]。女性的痴呆患病率和发病率均高于男性，2016 年分别为 3.138%[95%置信区间（3.127%-3.150%）]和 2.014%[95%置信区间（2.006%-2.022%）]，0.820[95%置信区间（0.814-0.826）]和 0.576 例/100 人[95%置信区间（0.571-0.580）]。
2000 年至 2016 年期间，糖尿病患者的痴呆患病率和发病率呈上升趋势。本研究增加了痴呆患病率和发病率的证据，特别是在糖尿病患者中。
