Adesuyan Matthew, Jani Yogini H, Alsugeir Dana, Howard Robert, Wong Ian C K, Wei Li, Brauer Ruth
Research Department of Practice and Policy UCL School of Pharmacy London UK.
Centre for Medicines Optimisation Research and Education University College London Hospitals NHS Foundation Trust London UK.
Alzheimers Dement (Amst). 2023 Jul 30;15(3):e12466. doi: 10.1002/dad2.12466. eCollection 2023 Jul-Sep.
We investigated trends in the incidence of dementia in UK adults with hypertension.
Primary care electronic health records from IQVIA Medical Research Data UK, previously known as THIN, were used to identify 2,133,118 adults aged ≥40 years with hypertension over 2000 to 2021. The annual incidence rate and average annual percentage change in recorded dementia diagnoses were estimated and stratified by sex, 10-year age bands, Townsend deprivation quintiles and dementia subtype.
The crude incidence rate of dementia in people with hypertension increased from 1.98 (95% confidence internal [CI] 1.89-2.07) per 1000 person-years at risk (PYAR) in 2000 to 5.29 per 1000 PYAR (95% CI 5.07-5.53) in 2021, corresponding to an average annual increase of 4.1% (95% CI 3.3-5.0). Those aged ≥80 years, the most economically deprived (Townsend = 5), and Alzheimer's disease subtype reported the highest incidence rate within their respective categories.
The annual incidence rate of dementia in the hypertensive population has increased over the last 22 years.
New dementia diagnosis in the hypertensive population has increased over 22 years.The Alzheimer's disease subtype reported the highest incidence rate in people with hypertension.Difference in dementia incidence between hypertensive females and males has reduced.Difference in dementia incidence among deprivation categories has reduced in recent years.
我们调查了英国高血压成年患者痴呆症发病率的趋势。
使用IQVIA英国医学研究数据（前身为THIN）中的初级保健电子健康记录，识别出2000年至2021年期间年龄≥40岁的2133118名高血压成年患者。估计了记录的痴呆症诊断的年发病率和年均百分比变化，并按性别、10岁年龄组、汤森贫困五分位数和痴呆症亚型进行分层。
高血压患者痴呆症的粗发病率从2000年的每1000人年风险（PYAR）1.98（95%置信区间[CI]1.89 - 2.07）增加到2021年的每1000 PYAR 5.29（95% CI 5.07 - 5.53），相当于年均增长4.1%（95% CI 3.3 - 5.0）。年龄≥80岁、经济最贫困（汤森 = 5）以及阿尔茨海默病亚型在各自类别中报告的发病率最高。
在过去22年中，高血压人群中痴呆症的年发病率有所增加。
在22年中，高血压人群中新的痴呆症诊断有所增加。阿尔茨海默病亚型在高血压患者中报告的发病率最高。高血压女性和男性之间痴呆症发病率的差异有所减小。近年来，贫困类别之间痴呆症发病率的差异有所减小。
