Ananchenko Anna, Hussein Toka O K, Mody Deepansh, Thompson Mackenzie J, Baenziger John E
Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada.
Biomolecules. 2022 Jun 10;12(6):814. doi: 10.3390/biom12060814.
Pentameric ligand-gated ion channels (pLGICs) play a leading role in synaptic communication, are implicated in a variety of neurological processes, and are important targets for the treatment of neurological and neuromuscular disorders. Endogenous lipids and lipophilic compounds are potent modulators of pLGIC function and may help shape synaptic communication. Increasing structural and biophysical data reveal sites for lipid binding to pLGICs. Here, we update our evolving understanding of pLGIC-lipid interactions highlighting newly identified modes of lipid binding along with the mechanistic understanding derived from the new structural data.
五聚体配体门控离子通道（pLGICs）在突触通讯中起主导作用，涉及多种神经学过程，并且是治疗神经和神经肌肉疾病的重要靶点。内源性脂质和亲脂性化合物是pLGIC功能的有效调节剂，可能有助于塑造突触通讯。越来越多的结构和生物物理数据揭示了脂质与pLGICs结合的位点。在这里，我们更新了对pLGIC-脂质相互作用的不断发展的理解，突出了新发现的脂质结合模式以及从新结构数据中获得的机制理解。
