Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Adv Protein Chem Struct Biol. 2020;121:143-168. doi: 10.1016/bs.apcsb.2019.11.010. Epub 2020 Jan 7.
Forkhead Box P3 (FOXP3) is a key transcriptional regulator of regulatory T cells (Tregs), especially for its function of immune suppression. The special immune suppression function of Tregs plays an important role in maintaining immune homeostasis, and is related to several diseases including cancer, and autoimmune diseases. At the same time, FOXP3 takes a place in a large transcriptional complex, whose stability and functions can be controlled by various post-translational modification. More and more researches have suggested that targeting FOXP3 or its partners might be a feasible solution to immunotherapy. In this review, we focus on the transcription factor FOXP3 in Tregs, Treg functions in diseases and the FOXP3 targets.
叉头框蛋白 P3（FOXP3）是调节性 T 细胞（Treg）的关键转录调节因子，特别是其免疫抑制功能。Treg 的特殊免疫抑制功能在维持免疫稳态方面发挥着重要作用，并与包括癌症和自身免疫性疾病在内的多种疾病有关。同时，FOXP3 占据了一个大型转录复合物的位置，其稳定性和功能可以通过各种翻译后修饰来控制。越来越多的研究表明，针对 FOXP3 或其伴侣可能是免疫治疗的一种可行方法。在这篇综述中，我们重点介绍了 Treg 中的转录因子 FOXP3、Treg 在疾病中的功能以及 FOXP3 的靶点。
